N-methyl-D-aspartate receptors and amnesia in mice with depression-like state

被引：0
|
作者：
N. I. Dubrovina
D. R. Zinovyev
D. V. Zinovyeva
机构：
[1] Siberian Division of the Russian Academy of Medical Sciences,Institute of Physiology
来源：
Bulletin of Experimental Biology and Medicine | 2007年 / 144卷
关键词：
memory; amnesia; depression; N-methyl-D-aspartate receptors;
D O I：
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学科分类号：
摘要：
We studied the effect of activation (N-methyl-D-aspartic acid and D-cycloserine) and blockade (dizocilpine and 7-chlorokynurenic acid) of N-methyl-D-aspartate receptors on the development of amnesia in intact and depressive mice under conditions of conditioned passive avoidance response. Agonists and antagonists of N-methyl-D-aspartate receptors produce a strong antiamnesic effect in mice with behavioral despair. In intact animals, only N-methyl-D-aspartic acid and D-cycloserine improved passive avoidance performance.
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页码：647 / 649
页数：2
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