Segmental duplications and the evolution of the primate genome

被引：0
作者：
Rhea Vallente Samonte
Evan E. Eichler
机构：
[1] School of Medicine and University Hospitals of Cleveland,Department of Genetics and Center for Human Genetics
[2] Case Western Reserve University,undefined
来源：
Nature Reviews Genetics | 2002年 / 3卷
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摘要：
Initial human genome sequence analysis has revealed large segments of nearly identical sequence in particular chromosomal regions. The recent origin of these segments and their abundance (∼5%) has challenged investigators to elucidate their underlying mechanism and role in primate genome evolution. Although the precise fraction is unknown, some of these duplicated segments have recently been shown to be associated with rapid gene innovation and chromosomal rearrangement in the genomes of man and the great apes.
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页码：65 / 72
页数：7
相关论文
共 110 条
[11]  
Eichler EE(1999)Exon shuffling by L1 retrotransposition Science 283 1530-1534
[12]  
Eichler EE(2000)The DNA sequence of human chromosome 21. The chromosome 21 mapping and sequencing consortium Nature 405 311-319
[13]  
Horvath J(2000)The genome sequence of Science 287 2185-2195
[14]  
Schwartz S(1999)Genetic definition and sequence analysis of Science 286 2468-2474
[15]  
Eichler E(1999) centromeres Genome Res. 9 1048-1058
[16]  
Tilford CA(2000)CAGGG repeats and the pericentromeric duplication of the hominoid genome Hum. Mol. Genet. 9 2029-2042
[17]  
Dombroski BA(1980)Genomic sequence and transcriptional profile of the boundary between pericentromeric satellites and genes on human chromosome arm 10q Science 209 1360-1365
[18]  
Mathias SL(1988)DNA sequences mediating class switching in α-immunoglobulins Nature 334 364-366
[19]  
Nanthakumar E(2000)Formation of parallel four-stranded complexes by guanine-rich motifs in DNA and its implications in meiosis Hum. Mol. Genet. 9 113-123
[20]  
Scott AF(1999)Molecular structure and evolution of an α/non-α satellite junction at 16p11 Hum. Mol. Genet. 8 205-215
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