Elevated paraneoplastic hypercholesterolemia in a case of hepatoid adenocarcinoma of the stomach with liver metastasis

被引：4

作者：

Sohda T. ^{[1
]}

Kusuhara H. ^{[2
]}

Egashira Y. ^{[2
]}

Egashira K. ^{[2
]}

Eguchi K. ^{[1
]}

Aoyagi K. ^{[1
]}

Sakisaka S. ^{[1
]}

机构：

[1] Department of Gastroenterology, Faculty of Medicine, Fukuoka University, Jonan-ku, Fukuoka 814-0180

[2] Sakura Hospital, Jonan-ku, Fukuoka 814-0142

来源：

Clinical Journal of Gastroenterology | 2013年 / 6卷 / 6期

关键词：

3-Hydroxyl-3- methylglutaryl coenzyme A (HMG-CoA) reductase; Alpha-fetoprotein (AFP); Des-gammacarboxy prothrombin (DCP); Hepatoid adenocarcinoma; Hypercholesterolemia; Paraneoplastic syndrome;

D O I：

10.1007/s12328-013-0420-z

中图分类号：

学科分类号：

摘要：

A 67-year-old man was admitted to our hospital because of a large liver tumor revealed by ultrasonography. Laboratory data showed increased serum levels of alpha-fetoprotein (AFP) and des-gamma-carboxy prothrombin (DCP), which are tumor markers for hepatocellular carcinoma. In addition, the serum cholesterol level was extremely high. Endoscopic examination revealed advanced gastric cancer. Histological findings of the stomach and liver tumor showed they were both hepatoid adenocarcinomas and were both positive for antibodies against AFP as well as DCP, suggesting that the tumors were gastric cancer with liver metastasis. Moreover, 3-hydroxyl-3-methylglutaryl coenzyme A (HMG-CoA) reductase, a key enzyme for regulation of cholesterol synthesis, was upregulated in the tumor tissues. Accordingly, we diagnosed this patient with AFP- and DCP-producing gastric cancer accompanied by paraneoplastic hypercholesterolemia. Paraneoplastic hypercholesterolemia is sometimes seen in hepatocellular carcinoma, but never in gastric cancer. This case is interesting because of the feature of hepatoid adenocarcinoma. © Springer 2013.

引用

页码：424 / 428

页数：4

共 14 条

[1]

McIntire K.R., Waldmann T.A., Moertel C.G., Go V.L., Serum alpha-fetoprotein in patients with neoplasms of the gastrointestinal tract, Cancer Res, 35, pp. 991-996, (1975)

[2]

Chang Y.C., Nagasue N., Abe S., Kohno H., Kumar D.D., Nakamura T., Alpha Fetoprotein producing early gastric cancer with liver metastasis: Report of three cases, Gut, 32, pp. 542-545, (1991)

[3]

Chang Y.C., Nagasue N., Abe S., Taniura H., Kumar D.D., Nakamura T., Comparison between the clinicopathologic features of AFP-positive and AFP-negative gastric cancers, Am J Gastroenterol, 87, pp. 321-325, (1992)

[4]

Ishikura H., Kirimoto K., Shamoto M., Hepatoid adenocarcinomas of the stomach: An analysis of seven cases, Cancer, 58, 1, pp. 119-126, (1986)

[5]

Luo J.C., Hwang S.-J., Wu J.-C., Li C.-P., Hsiao L.-T., Lai C.-R., Chiang J.-H., Lui W.-Y., Chang F.-Y., Lee S.-D., Paraneoplastic syndromes in patients with hepatocellular carcinoma in Taiwan, Cancer, 86, 5, pp. 799-804, (1999)

[6]

Hwang S.J., Lee S.D., Chang C.F., Wu J.C., Tsay S.H., Lui W.Y., Chiang J.H., Lo K.J., Hypercholesterolaemia in patients with hepatocellular carcinoma, J Gastroenterol Hepatol, 7, pp. 491-496, (1992)

[7]

Sohda T., Iwata K., Hirano G., Sakurai K., Yokoyama K., Morihara D., Takeyama Y., Irie M., Shakado S., Sakisaka S., 3-Hydroxyl-3-methylglutaryl-coenzyme A reductase is up regulated in hepatocellular carcinoma associated with paraneoplastic hypercholesterolemia, Med Mol Morphol, (2013)

[8]

Sohda T., Tomioka Y., Inomata S., Morita I., Eguchi K., Aoyagi K., Watanabe H., Nakamura S., Sakisaka S., Alpha-fetoprotein (AFP)- and des-gamma-carboxy prothrombin (DCP)- producing adenocarcinoma of the stomach with liver metastasis in a patient with chronic hepatitis C, Internal Medicine, 44, 4, pp. 294-298, (2005)

[9]

Ye M.F., Tao F., Liu F., Sun A.J., Hepatoid adenocarcinoma of the stomach: A report of three cases, World J Gastroenterol, 19, pp. 4437-4442, (2013)

[10]

Rodwell V.W., Cholesterol regulation of hepatic 3-hydroxy-3-methylglutaryl-coenzyme A reductase, Biochem J, 128, (1972)

← 1 2 →