Phase I study of veliparib in combination with gemcitabine

[1] Toschi L(2005)Role of gemcitabine in cancer therapy Future Oncol 1 7-17

[2] Finocchiaro G(1996)Gemcitabine: preclinical pharmacology and mechanisms of action Semin Oncol 23 3-15

[3] Bartolini S(1995)Preclinical characteristics of gemcitabine Anticancer Drugs 6 7-13

[4] Gioia V(1995)Gemcitabine: metabolism, mechanisms of action, and self-potentiation Semin Oncol 22 3-10

[5] Cappuzzo F(2002)Gemcitabine (2′,2′-difluoro-2′-deoxycytidine), an antimetabolite that poisons topoisomerase I Clin Cancer Res 8 2499-2504

[6] Plunkett W(2003)Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes J Biol Chem 278 20303-20312

[7] Huang P(2007)H2AX phosphorylation marks gemcitabine-induced stalled replication forks and their collapse upon S-phase checkpoint abrogation Mol Cancer Ther 6 1239-1248

[8] Searcy CE(2004)Poly(ADP-ribose) reactivates stalled DNA topoisomerase I and Induces DNA strand break resealing J Biol Chem 279 5244-5248

[9] Gandhi V(2005)The role of poly(ADP-ribose) in the DNA damage signaling network Biochem Cell Biol 83 354-364

[10] Plunkett W(2004)Effects of gemcitabine on APE/ref-1 endonuclease activity in pancreatic cancer cells, and the therapeutic potential of antisense oligonucleotides Br J Cancer 91 1166-1173

[1] Toschi L(2005)Role of gemcitabine in cancer therapy Future Oncol 1 7-17

[2] Finocchiaro G(1996)Gemcitabine: preclinical pharmacology and mechanisms of action Semin Oncol 23 3-15

[3] Bartolini S(1995)Preclinical characteristics of gemcitabine Anticancer Drugs 6 7-13

[4] Gioia V(1995)Gemcitabine: metabolism, mechanisms of action, and self-potentiation Semin Oncol 22 3-10

[5] Cappuzzo F(2002)Gemcitabine (2′,2′-difluoro-2′-deoxycytidine), an antimetabolite that poisons topoisomerase I Clin Cancer Res 8 2499-2504

[6] Plunkett W(2003)Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes J Biol Chem 278 20303-20312

[7] Huang P(2007)H2AX phosphorylation marks gemcitabine-induced stalled replication forks and their collapse upon S-phase checkpoint abrogation Mol Cancer Ther 6 1239-1248

[8] Searcy CE(2004)Poly(ADP-ribose) reactivates stalled DNA topoisomerase I and Induces DNA strand break resealing J Biol Chem 279 5244-5248

[9] Gandhi V(2005)The role of poly(ADP-ribose) in the DNA damage signaling network Biochem Cell Biol 83 354-364

[10] Plunkett W(2004)Effects of gemcitabine on APE/ref-1 endonuclease activity in pancreatic cancer cells, and the therapeutic potential of antisense oligonucleotides Br J Cancer 91 1166-1173