Injectable tissue prosthesis for instantaneous closed-loop rehabilitation

被引:0
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作者
Subin Jin
Heewon Choi
Duhwan Seong
Chang-Lim You
Jong-Sun Kang
Seunghyok Rho
Won Bo Lee
Donghee Son
Mikyung Shin
机构
[1] Sungkyunkwan University,Department of Intelligent Precision Healthcare Convergence
[2] Center for Neuroscience Imaging Research,Department of Electrical and Computer Engineering
[3] Institute for Basic Science,Department of Molecular Cell Biology, Single Cell Network Research Center, School of Medicine
[4] Sungkyunkwan University,School of Chemical and Biological Engineering, Institute of Chemical Processes
[5] Sungkyunkwan University,Department of Superintelligence Engineering
[6] Seoul National University,Department of Biomedical Engineering, SKKU Institute for Convergence
[7] Sungkyunkwan University,undefined
[8] Sungkyunkwan University,undefined
来源
Nature | 2023年 / 623卷
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摘要
To construct tissue-like prosthetic materials, soft electroactive hydrogels are the best candidate owing to their physiological mechanical modulus, low electrical resistance and bidirectional stimulating and recording capability of electrophysiological signals from biological tissues1,2. Nevertheless, until now, bioelectronic devices for such prostheses have been patch type, which cannot be applied onto rough, narrow or deep tissue surfaces3–5. Here we present an injectable tissue prosthesis with instantaneous bidirectional electrical conduction in the neuromuscular system. The soft and injectable prosthesis is composed of a biocompatible hydrogel with unique phenylborate-mediated multiple crosslinking, such as irreversible yet freely rearrangeable biphenyl bonds and reversible coordinate bonds with conductive gold nanoparticles formed in situ by cross-coupling. Closed-loop robot-assisted rehabilitation by injecting this prosthetic material is successfully demonstrated in the early stage of severe muscle injury in rats, and accelerated tissue repair is achieved in the later stage.
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页码:58 / 65
页数:7
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