Primary leiomyosarcoma of the colon

被引：14

作者：

Kono M. ^{[1
]}

Tsuji N. ^{[1
]}

Ozaki N. ^{[1
]}

Matsumoto N. ^{[1
]}

Takaba T. ^{[1
]}

Okumura N. ^{[1
]}

Kawasaki M. ^{[1
]}

Tomita T. ^{[1
]}

Umehara Y. ^{[1
]}

Taniike S. ^{[1
]}

Hatabe S. ^{[2
]}

Funai S. ^{[2
]}

Ono Y. ^{[3
]}

Ochiai K. ^{[4
]}

Maekura S. ^{[4
]}

Kudo M. ^{[5
]}

机构：

[1] Department of Gastroenterology, Sakai Hospital Kinki University Faculty of Medicine, 2-7-1 Harayamadai, Minamiku, Sakai

[2] Department of Surgery, Sakai Hospital Kinki University Faculty of Medicine, 2-7-1 Harayamadai, Minamiku, Sakai

[3] Department of Radiology, Sakai Hospital Kinki University Faculty of Medicine, 2-7-1 Harayamadai, Minamiku, Sakai

[4] Department of Pathology, Sakai Hospital Kinki University Faculty of Medicine, 2-7-1 Harayamadai, Minamiku, Sakai

[5] Department of Gastroenterology and Hepatology, Kinki University Faculty of Medicine, 377-2 Onohigashi, Osaka-Sayama

来源：

Clinical Journal of Gastroenterology | 2015年 / 8卷 / 4期

关键词：

Colonic mesenchymal tumor; GIST; Leiomyosarcoma;

D O I：

10.1007/s12328-015-0584-9

中图分类号：

学科分类号：

摘要：

Primary leiomyosarcomas of the gastrointestinal (GI) tract are extremely rare and highly aggressive neoplasms, and only a small number of true cases have been reported since the concept of GI stromal tumors was established. Here, we report a case of a primary leiomyosarcoma of the transverse colon. A 46-year-old Japanese male with a large mass in the right upper abdomen was admitted to our hospital. Computed tomography and magnetic resonance imaging revealed long segments of wall thickening of the transverse colon with large consecutive tumors measuring 12 cm in diameter. A projecting irregular mass with marked mucosal necrosis was found on colonoscopy. Pathological examination revealed a spindle cell tumor growing circumferentially and transmurally to replace the muscularis propria in the transverse colon. The spindle cells were positive for smooth muscle actin, and negative for KIT, CD34, DOG-1, and S-100 protein. The patient has shown repeat recurrence in spite of sufficient surgical excision being promptly performed. © 2015, Springer Japan.

引用

页码：217 / 222

页数：5

共 21 条

[1] Hirota S., Isozaki K., Moriyama Y., Et al., Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors, Science, 279, pp. 577-580, (1998)
[2] Miettinen M., Sarlomo-Rikala M., Sobin L.H., Mesenchymal tumors of muscularis mucosae of colon and rectum are benign leiomyomas that should be separated from gastrointestinal stromal tumors—a clinicopathologic and immunohistochemical study of eighty-eight cases, Mod Pathol, 14, pp. 950-956, (2001)
[3] Hirota S., Isozaki K., Pathology of gastrointestinal stromal tumors, Pathol Int, 56, pp. 1-9, (2006)
[4] Miettinen M., Sarlomo-Rikala M., Sobin L.H., Lasota J., Gastrointestinal stromal tumors and leiomyosarcomas in the colon: a clinicopathologic, immunohistochemical, and molecular genetic study of 44 cases, Am J Surg Pathol, 24, pp. 1339-1352, (2000)
[5] Aggarwal G., Sharma S., Zheng M., Et al., Primary leiomyosarcomas of the gastrointestinal tract in the post-gastrointestinal stromal tumor era, Ann Diagn Pathol, 16, pp. 532-540, (2012)
[6] Yamamoto H., Handa M., Tobo T., Et al., Clinicopathological features of primary leiomyosarcoma of the gastrointestinal tract following recognition of gastrointestinal stromal tumours, Histopathology, 63, pp. 194-207, (2013)
[7] Hirota S., Ohashi A., Nishida T., Et al., Gain-of-function mutations of platelet-derived growth factor receptor alpha gene in gastrointestinal stromal tumors, Gastroenterology, 125, pp. 660-667, (2003)
[8] Miettinen M., Furlong M., Sarlomo-Rikala M., Et al., Gastrointestinal stromal tumors, intramural leiomyomas, and leiomyosarcomas in the rectum and anus: a clinicopathologic, immunohistochemical, and molecular genetic study of 144 cases, Am J Surg Pathol, 25, pp. 1121-1133, (2001)
[9] Miettinen M., Lasota J., Gastrointestinal stromal tumors: review on morphology, molecular pathology, prognosis, and differential diagnosis, Arch Pathol Lab Med, 130, pp. 1466-1478, (2006)
[10] Agaimy A., Wunsch P.H., True smooth muscle neoplasms of the gastrointestinal tract: morphological spectrum and classification in a series of 85 cases from a single institute, Langenbecks Arch Surg, 392, pp. 75-81, (2007)

← 1 2 3 →