New issues in heart transplantation for heart failure

被引：7
作者：
Michelle M. Kittleson
机构：
[1] Beverly Hills, CA 90211
来源：
Current Treatment Options in Cardiovascular Medicine | 2012年 / 14卷 / 4期
关键词：
AlloMap; Antimetabolites; Antithymocyte globulin; Basiliximab; Biopsy; Bortezomib; Calcineurin inhibitors; Corticosteroids; Cylex; Heart failure; Immunosuppression; Intravenous immunoglobulin; Photopheresis; Plasmapheresis; Proliferation signal inhibitors; Rituximab; Transplant;
D O I：
10.1007/s11936-012-0184-7
中图分类号：
学科分类号：
摘要：
Heart transplantation is the preferred therapy for patients with end-stage heart failure with refractory symptoms despite optimal medical and device therapy. The major impediment to survival is rejection and infection in the short term and cardiac allograft vasculopathy and malignancy in the long term. Current therapies are focused on the prevention and treatment of rejection and limiting the long-term problems of cardiac allograft vasculopathy and malignancy. Advances in monitoring assays now allow better assessment of rejection and the level of immune response. This will allow clinicians, in the future, to tailor current therapies to the needs of individual heart transplant recipients to maximize benefit and minimize toxicity. © Springer Science+Business Media, LLC 2012.
引用
收藏
页码：356 / 369
页数：13
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