Effect of amlodipine on the growth of vascular smooth muscle cells of spontaneously hypertensive rats

被引：0
作者：
Tang Jiarong
Liu Zhengxiang
Ren Dahong
Wu Cuihuan
机构：
[1] Tongji Medical University,Department of Cardiology, Tongji Hospital
[2] Tongji Medical University,Department of Pathology
来源：
Current Medical Science | 1997年 / 17卷 / 3期
关键词：
amlodipine; neuropeptide Y; vascular smooth muscle cells;
D O I：
10.1007/BF02888294
中图分类号：
学科分类号：
摘要：
The effect of anti-hypertensive drug amlodipine on regression of cardiovascular hypertrophy due to hypertension was studied by using cultured smooth muscle cells derived from arteries of spontaneously hypertensive rats (SHR) and measuring [3H]-TdR and [3H]-Leucine binding. 48 h after adding amlodipine, [3H] -TdR binding in arterial smooth muscle cells from SHRin vitro was reduced by 50. 5 % and [3H]-Leucine binding was reduced by 56. 2 % as compared with neuropeptide Y(NPY)-treated group. However, there was no significant change in cell number. The results showed that amlodipine could effectively inhibit increase of DNA and protein synthesis of vascular smooth muscle cell (VSMC) due to NPY. It indicates that amlodipine is of great significance on regression of genesis and development of cardiovascular hypertrophy due to hypertension.
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页码：165 / 167
页数：2
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