Lamin A/C Cardiomyopathy: Implications for Treatment

被引:0
作者
Suet Nee Chen
Orfeo Sbaizero
Matthew R. G. Taylor
Luisa Mestroni
机构
[1] University of Colorado Denver Anschutz Medical Campus,Molecular Genetics, Cardiovascular Institute
[2] University of Trieste (Italy),Department of Engineering and Architecture
来源
Current Cardiology Reports | 2019年 / 21卷
关键词
Lamin A/C gene; Laminopathy; Heart failure; Arrhythmias; Mechanotransduction; P53; CRISPR–Cas9 therapy;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 677 条
[1]  
Mestroni L(2014)Genetic causes of dilated cardiomyopathy Prog Pediatr Cardiol 37 13-18
[2]  
Brun F(2000)Lamin A/C gene mutation associated with dilated cardiomyopathy with variable skeletal muscle involvement Circulation. 101 473-476
[3]  
Spezzacatene A(2012)Risk factors for malignant ventricular arrhythmias in lamin a/c mutation carriers a European cohort study J Am Coll Cardiol 59 493-500
[4]  
Sinagra G(2016)Long-term arrhythmic and nonarrhythmic outcomes of lamin A/C mutation carriers J Am Coll Cardiol 68 2299-2307
[5]  
Taylor MR(2015)Lamins at the crossroads of mechanosignaling Genes Dev 29 225-237
[6]  
Brodsky GL(2014)Cellular mechanosensing: getting to the nucleus of it all Prog Biophys Mol Biol 115 76-92
[7]  
Muntoni F(2004)Defects in nuclear structure and function promote dilated cardiomyopathy in lamin A/C-deficient mice J Clin Invest 113 357-369
[8]  
Miocic S(2004)Lamin A/C deficiency causes defective nuclear mechanics and mechanotransduction J Clin Invest 113 370-378
[9]  
Sinagra G(2010)Effects of mechanical stress and carvedilol in lamin A/C-deficient dilated cardiomyopathy Circ Res 106 573-582
[10]  
Sewry C(2005)Meta-analysis of clinical characteristics of 299 carriers of LMNA gene mutations: do lamin A/C mutations portend a high risk of sudden death? J Mol Med (Berl) 83 79-83