Hypercapnic acidosis in ventilator-induced lung injury

[1] Hickling KG(1994)Low mortality rate in adult respiratory distress syndrome using low-volume, pressure-limited ventilation with permissive hypercapnia: a prospective study Crit Care Med 22 1568-1578

[2] Walsh J(2000)Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The acute respiratory distress syndrome network N Engl J Med 342 1301-1308

[3] Henderson S(2002)The lung and carbon dioxide: implications for permissive and therapeutic hypercapnia Eur Respir J 20 6-11

[4] Jackson R(2000)Biological effects of hypercapnia (Review) Intens Care Med 26 133-138

[5] Hickling KG(2006)Hypercapnic acidosis and mortality in acute lung injury Crit Care Med 34 1-7

[6] Kregenow DA(1999)Carbon dioxide and the critically ill—too little of a good thing? (Hypothesis Paper) Lancet 354 1283-1286

[7] Swenson ER(1998)Hypercapnic acidosis may attenuate acute lung injury by inhibition of endogenous xanthine oxidase Am J Resp Crit Care Med 158 1578-1584

[8] Laffey JG(2008)Hypercapnic acidosis attenuates the pulmonary innate immune response in ventilated healthy mice Crit Care Med 36 2403-2406

[9] Kavanagh BP(2002)Hypercapnic acidosis is protective in an in vivo model of ventilator-induced lung injury Am J Respir Crit Care Med 166 403-408

[10] Kregenow DA(2003)Effects of high PCO2 on ventilated preterm lamb lungs Pediatr Res 53 468-472

[1] Hickling KG(1994)Low mortality rate in adult respiratory distress syndrome using low-volume, pressure-limited ventilation with permissive hypercapnia: a prospective study Crit Care Med 22 1568-1578

[2] Walsh J(2000)Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The acute respiratory distress syndrome network N Engl J Med 342 1301-1308

[3] Henderson S(2002)The lung and carbon dioxide: implications for permissive and therapeutic hypercapnia Eur Respir J 20 6-11

[4] Jackson R(2000)Biological effects of hypercapnia (Review) Intens Care Med 26 133-138

[5] Hickling KG(2006)Hypercapnic acidosis and mortality in acute lung injury Crit Care Med 34 1-7

[6] Kregenow DA(1999)Carbon dioxide and the critically ill—too little of a good thing? (Hypothesis Paper) Lancet 354 1283-1286

[7] Swenson ER(1998)Hypercapnic acidosis may attenuate acute lung injury by inhibition of endogenous xanthine oxidase Am J Resp Crit Care Med 158 1578-1584

[8] Laffey JG(2008)Hypercapnic acidosis attenuates the pulmonary innate immune response in ventilated healthy mice Crit Care Med 36 2403-2406

[9] Kavanagh BP(2002)Hypercapnic acidosis is protective in an in vivo model of ventilator-induced lung injury Am J Respir Crit Care Med 166 403-408

[10] Kregenow DA(2003)Effects of high PCO2 on ventilated preterm lamb lungs Pediatr Res 53 468-472