The association of HLA-B*27 subtypes with ankylosing spondylitis in Wuhan population of China

被引：0
作者：
Xiang Liu
Li-Hua Hu
Yi-Rong Li
Feng-Hua Chen
Yong Ning
Qun-Feng Yao
机构：
[1] Huazhong University of Science and Technology,Clinical Laboratory Medicine Department, Union Hospital, Tongji Medical College
[2] Hubei College of Traditional Chinese Medicine,Department of Medical Laboratory and Technology
来源：
Rheumatology International | 2010年 / 30卷
关键词：
Human leukocyte antigen; Wuhan; HLA-B27; Subtypes; Ankylosing spondylitis;
D O I：
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学科分类号：
摘要：
The aim of this study was to investigate the association of the B27 subtypes with ankylosing spondylitis (AS) in the Wuhan population of China. We selected 317 HLA-B27-positive individuals (145 controls and 172 patients with ankylosing spondylitis). The B27 subtypes were characterized using a PCR-SSP method. Six B27 subtypes were determined: B*2702, 03, 04, 05, 06 and B*13. HLA-B*2704 and HLA-B*2705 were the two high frequency genotypes in controls and patients. Compared with the controls, the AS patients had high frequency of B*2704 (patients 69.2% vs. controls 53.8%) and low frequency of B*2705 (patients 23.8% vs. controls 33.1%). B*2703 was detected in 10 (5.8%) patients and in 13 (8.9%) controls. B*2702, 06 and B*2713 were relatively rare. Our results show that the allele conferring risk to AS in the Wuhan population of China was B*2704 and B*2705. B*2704 is strongly associated with AS.
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页码：587 / 590
页数：3
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