A folic acid-based functionalized surface for biosensor systems

被引：0
|
作者：
Kaustubh D. Bhalerao
Stephen C. Lee
Winston O. Soboyejo
Alfred B. O. Soboyejo
机构：
[1] University of Illinois at Urbana-Champaign,Department of Agricultural and Biological Engineering
[2] The Ohio State University,Department of Biomedical Engineering, Department of Chemical Engineering and The Davis Heart & Lung Institute
[3] Princeton University,Department of Mechanical and Aerospace Engineering and The Princeton Materials Institute
[4] The Ohio State University,Department of Food, Agricultural and Biological Engineering, Department of Aerospace Engineering and The John Glenn Institute of Public Policy and Public Service
来源：
Journal of Materials Science: Materials in Medicine | 2007年 / 18卷
关键词：
Folic Acid; Titanium Surface; Folate Receptor; Micro Electro Mechanical System; Reduce Folate Carrier;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The performance of a biosensor depends largely on its interface with the biological system. This interface imparts a biologically relevant function to the device and provides a measure of specificity towards the biological analyte of interest. This paper documents the choice of folic acid as the functional component of a cantilever sensor to recognize nasopharyngeal (KB) cancer cells. A conjugation chemistry protocol has been outlined to deploy folic acid onto a titanium-coated sensor surface using a silane linker. The presence and biological activity of the sensor was verified by means of an immmunospecific (ELISA) procedure. The overall performance of the folic acid-based cantilever sensor was measured using cancerous KB cell-binding experiments.
引用
收藏
页码：3 / 8
页数：5
相关论文
共 50 条
  • [1] A folic acid-based functionalized surface for biosensor systems
    Bhalerao, Kaustubh D.
    Lee, Stephen C.
    Soboyejo, Winston O.
    Soboyejo, Alfred B. O.
    JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2007, 18 (01) : 3 - 8
  • [2] Synthesis of folic acid functionalized, tannic acid-based gold quantum dots for potential use in various applications
    Kartikey J. Chavan
    Sarang R. Bhagwat
    Gayatri M. Gaidhane
    Bhimarao M. Patil
    Taeyeob Kim
    Hansol Kang
    Arpita Pandey Tiwari
    Insik In
    Ravindra N. Bulakhe
    Ji Man Kim
    Journal of Materials Science: Materials in Electronics, 2023, 34
  • [3] Synthesis of folic acid functionalized, tannic acid-based gold quantum dots for potential use in various applications
    Chavan, Kartikey J.
    Bhagwat, Sarang R.
    Gaidhane, Gayatri M.
    Patil, Bhimarao M.
    Kim, Taeyeob
    Kang, Hansol
    Tiwari, Arpita Pandey
    In, Insik
    Bulakhe, Ravindra N.
    Kim, Ji Man
    JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS, 2023, 34 (31)
  • [4] Ferroceneboronic acid-based amperometric biosensor for glycated hemoglobin
    Liu, SQ
    Wollenberger, U
    Katterle, M
    Scheller, FW
    SENSORS AND ACTUATORS B-CHEMICAL, 2006, 113 (02) : 623 - 629
  • [5] Biosensor-based determination of folic acid in fortified food
    Caselunghe, MB
    Lindeberg, J
    FOOD CHEMISTRY, 2000, 70 (04) : 523 - 532
  • [6] Folic acid-based supramolecules for enhanced stability in potassium ion batteries
    Yanan Wang
    Dandan Ouyang
    Liuqian Yang
    Chunyan Wang
    Jian Sun
    Hui Zhu
    Jiao Yin
    ChineseChemicalLetters, 2023, 34 (09) : 302 - 306
  • [7] Folic acid-based supramolecules for enhanced stability in potassium ion batteries
    Wang, Yanan
    Ouyang, Dandan
    Yang, Liuqian
    Wang, Chunyan
    Sun, Jian
    Zhu, Hui
    Yin, Jiao
    CHINESE CHEMICAL LETTERS, 2023, 34 (09)
  • [8] Stress makes cells resistant to folic acid-based chemotherapeutic agents
    Ahrends R.
    Medenbach J.
    BIOspektrum, 2020, 26 (6) : 609 - 611
  • [9] Folic acid functionalized nanoparticles as pharmaceutical carriers in drug delivery systems
    Narmani, Asghar
    Rezvani, Melina
    Farhood, Bagher
    Darkhor, Parvaneh
    Mohammadnejad, Javad
    Amini, Bahram
    Refahi, Soheila
    Goushbolagh, Nouraddin Abdi
    DRUG DEVELOPMENT RESEARCH, 2019, 80 (04) : 404 - 424
  • [10] Folic acid-functionalized zirconium metal-organic frameworks based electrochemical impedance biosensor for the cancer cell detection
    Du, Liping
    Chen, Wei
    Wang, Jian
    Cai, Wen
    Kong, Shu
    Wu, Chunsheng
    SENSORS AND ACTUATORS B-CHEMICAL, 2019, 301
12345