Predictors of immune reconstitution inflammatory syndrome associated with Kaposi’s sarcoma: a case report

被引：0

作者：

Anna Maria Cattelan

Adriana Mattiolo

Angela Grassi

Maria Assunta Piano

Lolita Sasset

Marco Trevenzoli

Paola Zanovello

Maria Luisa Calabrò

机构：

[1] Azienda Ospedaliera and University of Padova,Infectious and Tropical Diseases

[2] Veneto Institute of Oncology,Immunology and Molecular Oncology

[3] IOV IRCCS,Department of Infectious and Tropical Diseases

[4] Infectious Diseases,Department of Surgery, Oncology and Gastroenterology

[5] ULSS 18 - Azienda Ospedaliera,undefined

[6] University of Padova,undefined

[7] School of Medicine,undefined

[8] University of Padova,undefined

来源：

Infectious Agents and Cancer | / 11卷

关键词：

Immune reconstitution inflammatory syndrome; IRIS; Kaposi’s sarcoma; KS; KS-IRIS; HHV8; KSHV; Biomarker;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

We present here a case of immune reconstitution inflammatory syndrome associated with Kaposi’s sarcoma (KS-IRIS) developed in an AIDS patient two months after initiation of antiretroviral therapy (ART). Baseline characteristics of this IRIS-KS case, within a cohort of 12 naïve AIDS-KS patients, were analyzed. No statistically significant differences in CD4 cell counts, plasma HIV RNA load, KS clinical staging, human herpesvirus 8 (HHV8) antibody titers and HHV8 load in peripheral blood mononuclear cells and saliva were evidenced. HHV8 load in plasma was found to be significantly higher in the KS-IRIS patient (> 6 log10 genome equivalents/ml, p = 0.01, t–test) compared to the 11 patients with KS regression. This case highlights that measurement of HHV8 load in plasma may be useful to identify patients at risk for KS-IRIS, and that this parameter should be included in the design of larger studies to define KS-IRIS risk predictors.

引用

共 65 条

[1]

Müller M(2010)Immune reconstitution inflammatory syndrome in patients starting antiretroviral therapy for HIV infection: a systematic review and meta-analysis Lancet Infect Dis 10 251-61

[2]

Wandel S(2008)Biomarkers of HIV Immune Reconstitution Inflammatory Syndrome Biomark Med 2 349-61

[3]

Colebunders R(2010)Biomarkers in immune reconstitution inflammatory syndrome: signals from pathogenesis Curr Opin HIV AIDS 5 504-10

[4]

Attia S(2008)Insights into pathogenic events of HIV-associated Kaposi sarcoma and immune reconstitution syndrome related Kaposi sarcoma Infect Agent Cancer. 3 1-27

[5]

Furrer H(2004)Immune restoration disease after antiretroviral therapy AIDS 18 1615-13

[6]

Egger M(2013)Immune reconstitution inflammatory syndrome associated with Kaposi sarcoma: higher incidence and mortality in Africa than in the UK AIDS 27 1603-9

[7]

Bonham S(2010)Evaluation of plasma human herpesvirus 8 DNA as a marker of clinical outcomes during antiretroviral therapy for AIDS-related Kaposi sarcoma in Zimbabwe Clin Infect Dis 51 342-85

[8]

Meya DB(2005)Long-term clinical outcome of AIDS-related Kaposi’s sarcoma during highly active antiretroviral therapy Int J Oncol 27 779-9

[9]

Bohjanen PR(2001)Acquired immunodeficiency syndrome-related Kaposi’s sarcoma regression after highly active antiretroviral therapy: biologic correlates of clinical outcome J Natl Cancer Inst Monogr. 28 44-75

[10]

Boulware DR(2005)Use of a BJAB-derived cell line for isolation of human herpesvirus 8 J Clin Microbiol 43 2866-6

← 1 2 3 4 5 6 7 →