Detrimental Effects of Maternal Lead Exposure during Pregnancy and Lactation on Molar Development in the Young Rat

被引：0
作者：
Hong-Sen Chen
Yu-Chen Tsai
Ker-Kong Chen
Yu-Chuan Tseng
Kun-Jung Hsu
机构：
[1] Kaohsiung Medical University,Department of Oral Hygiene, College of Dental Medicine
[2] Kaohsiung Medical University,School of Dentistry, College of Dental Medicine
[3] Kaohsiung Medical University,Department of Pediatric Dentistry, Kaohsiung Medical University Hospital
[4] Kaohsiung Medical University,Department of Conservative Dentistry, Kaohsiung Medical University Hospital
[5] Kaohsiung Medical University,Department of Orthodontics, Kaohsiung Medical University Hospital
[6] Kaohsiung Medical University,Department of Family Dentistry, Kaohsiung Medical University Hospital
来源：
Bulletin of Environmental Contamination and Toxicology | 2012年 / 89卷
关键词：
Rat; Molar; Lead exposure; Morphology; Pregnancy; Lactation;
D O I：
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中图分类号：
学科分类号：
摘要：
The purpose of this animal study was to investigate the influence of maternal lead exposure during pregnancy and lactation on molar development in the offspring. Scanning electron microscopy revealed no significant differences in the molar morphology among the groups. However, in all the experimental groups, deep, wide cracks were found in the occlusal enamel. Further, the experimental groups had smaller molar diameters than the control group, lead exposure during lactation had a greater influence on the molar size in the offspring, and the groups with the higher dose of lead exposure during pregnancy and lactation had significantly smaller molar sizes than the groups that received the lower dose. The mesiodistal and buccolingual diameters of molars were measured as 3.10 ± 0.07 and 1.95 ± 0.04 mm for control group, 2.97 ± 0.08 and 1.94 ± 0.01 mm for lactation group of low dose, 2.96 ± 0.05 and 1.84 ± 0.02 mm for lactation group of high dose, 3.09 ± 0.06 and 1.94 ± 0.04 mm for pregnancy group of low dose, and 3.02 ± 0.06 and 1.85 ± 0.06 mm for pregnancy group of high dose, respectively.
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页码：240 / 244
页数：4
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