Laccase-Catalyzed Heterocoupling of Dihydroquercetin and p-Aminobenzoic Acid: Effect of the Reaction Product on Cultured Cells

被引：0
|
作者：
M. E. Khlupova
O. V. Morozova
I. S. Vasil’eva
G. P. Shumakovich
N. V. Pashintseva
L. I. Kovalev
S. S. Shishkin
V. A. Chertkov
A. K. Shestakova
A. V. Kisin
A. I. Yaropolov
机构：
[1] Russian Academy of Sciences,Research Center of Biotechnology, Bach Institute of Biochemistry
[2] Lomonosov Moscow State University,undefined
[3] Faculty of Chemistry,undefined
[4] State Research Institute of Chemistry and Technology of Organoelement Compounds,undefined
来源：
Biochemistry (Moscow) | 2018年 / 83卷
关键词：
dihydroquercetin; -aminobenzoic acid; laccase; biotransformation; H and ; C NMR spectra; proteomics;
D O I：
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学科分类号：
摘要：
Derivatization of the natural flavonoid dihydroquercetin with p-aminobenzoic acid was carried out in an ethyl acetate/citric buffer biphasic system using laccase from the fungus Trametes hirsuta. The main reaction product yield was ~68 mol %. The product was characterized by 1H NMR, 13C NMR, and liquid chromatography-mass spectroscopy, and its structure was elucidated. The reaction product affected viability of cultured human rhabdomyosarcoma cells (RD cell line) in a dose-dependent manner and, therefore, can be of interest to pharmaceutical industry.
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页码：992 / 1001
页数：9
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