Elevated plasma levels of transforming growth factor (TGF)-β1 and TGF-β2 in patients with disseminated malignant melanoma

被引：0

作者：

K Krasagakis

D Thölke

B Farthmann

J Eberle

U Mansmann

CE Orfanos

机构：

[1] University Medical Center Benjamin Franklin,Department of Dermatology

[2] The Free University of Berlin,undefined

来源：

British Journal of Cancer | 1998年 / 77卷

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摘要：

Overexpression of transforming growth factor-beta isoforms (TGF-beta1, -beta2, -beta3) has been previously reported in human melanoma cell lines and tumours. The aim of the present study was to evaluate the plasma levels of TGF-beta isoforms in melanoma patients. Significantly elevated levels of TGF-beta1 (4.2 x the controls, P = 0.0094) and of TGF-beta2 (1.5 x the controls, P = 0.012) but not of TGF-beta3 were measured in patients with disseminated but not locoregional melanoma. These results indicate systemic circulation of potentially immunosuppressive peptides of the TGF-beta family in end-stage melanoma patients.

引用

页码：1492 / 1494

页数：2