An A2Aadenosine receptor agonist, ATL313, reduces inflammation and improves survival in murine sepsis models

[1] Martin GS(2003)The epidemiology of sepsis in the United States from 1979 through 2000 N Engl J Med 348 1546-54

[2] Mannino DM(1997)Anti-inflammatory therapies to treat sepsis and septic shock: a reassessment Crit Care Med 25 1095-100

[3] Eaton S(2001)Efficacy and safety of recombinant human activated protein C for severe sepsis N Engl J Med 344 699-709

[4] Moss M(2003)The critical role of adenosine A2A receptors in downregulation of inflammation and immunity in the pathogenesis of infectious diseases Microbes Infect 5 515-26

[5] Zeni F(2001)Cyclic AMP-dependent inhibition of human neutrophil oxidative activity by substituted 2-propynylcyclohexyl adenosine A(2A) receptor agonists Br J Pharmacol 132 1017-26

[6] Freeman B(2001)Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damage Nature 414 916-20

[7] Natanson C(2006)Both gram-negative and gram-positive experimental pneumonia induce profound lymphocyte but not respiratory epithelial cell apoptosis Shock 26 271-6

[8] Bernard GR(1996)Genetic mapping of a murine locus controlling development of T helper 1/T helper 2 type responses Proc Natl Acad Sci USA 93 12467-72

[9] Vincent JL(1996)Immunologic dissonance: A continuing evolution in our understanding of the systemic inflammatory response syndrome (SIRS) and the multiple organ dysfunction syndrome (MODS) Annals of Internal Medicine 125 680-687

[10] Laterre PF(2005)A2A adenosine receptor induction inhibits IFN-gamma production in murine CD4+ T cells J Immunol 174 1073-80

[1] Martin GS(2003)The epidemiology of sepsis in the United States from 1979 through 2000 N Engl J Med 348 1546-54

[2] Mannino DM(1997)Anti-inflammatory therapies to treat sepsis and septic shock: a reassessment Crit Care Med 25 1095-100

[3] Eaton S(2001)Efficacy and safety of recombinant human activated protein C for severe sepsis N Engl J Med 344 699-709

[4] Moss M(2003)The critical role of adenosine A2A receptors in downregulation of inflammation and immunity in the pathogenesis of infectious diseases Microbes Infect 5 515-26

[5] Zeni F(2001)Cyclic AMP-dependent inhibition of human neutrophil oxidative activity by substituted 2-propynylcyclohexyl adenosine A(2A) receptor agonists Br J Pharmacol 132 1017-26

[6] Freeman B(2001)Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damage Nature 414 916-20

[7] Natanson C(2006)Both gram-negative and gram-positive experimental pneumonia induce profound lymphocyte but not respiratory epithelial cell apoptosis Shock 26 271-6

[8] Bernard GR(1996)Genetic mapping of a murine locus controlling development of T helper 1/T helper 2 type responses Proc Natl Acad Sci USA 93 12467-72

[9] Vincent JL(1996)Immunologic dissonance: A continuing evolution in our understanding of the systemic inflammatory response syndrome (SIRS) and the multiple organ dysfunction syndrome (MODS) Annals of Internal Medicine 125 680-687

[10] Laterre PF(2005)A2A adenosine receptor induction inhibits IFN-gamma production in murine CD4+ T cells J Immunol 174 1073-80