Remodeling of excitation-contraction coupling in the heart: Inhibition of sarcoplasmic reticulum Ca2+ leak as a novel therapeutic approach

被引：19

作者：

Neef S. ^{[1
]}

Maier L.S. ^{[1
]}

机构：

[1] Abt. Kardiologie and Pneumologie/Herzzentrum, Georg-August-Universität Göttingen, 37075 Göttingen

来源：

Current Heart Failure Reports | 2007年 / 4卷 / 1期

关键词：

Sarcoplasmic Reticulum; Ryanodine Receptor; Calcium Release Channel; Cardiac Ryanodine Receptor; SERCA2a Protein;

D O I：

10.1007/s11897-007-0020-7

中图分类号：

学科分类号：

摘要：

In the heart, excitation-contraction coupling is the central mechanism by which electrical activation is translated into cardiac contraction. In heart failure, several proteins involved in this finely concerted regulation are changed with respect to expression, phosphorylation status, and function leading to remodeling of excitation-contraction coupling. The present review article summarizes well known alterations in heart failure and focuses on recent findings especially regarding altered sarcoplasmic reticulum Ca2+ release process due to two distinct kinases, namely protein kinase A and Ca 2+/calmodulin-dependent kinase II. Furthermore, it highlights the translation of those findings into possible novel therapeutic approaches. Copyright © 2007 by Current Medicine Group LLC.

引用

页码：11 / 17

页数：6

共 50 条

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