The role of Müller glia and microglia in glaucoma

被引：0
作者：
Roswitha Seitz
Andreas Ohlmann
Ernst R. Tamm
机构：
[1] University of Regensburg,Institute of Human Anatomy and Embryology
来源：
Cell and Tissue Research | 2013年 / 353卷
关键词：
Glaucoma; Microglia; Müller glia; Neuroprotection; Retina;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Cells of Müller glia and microglia react to neuronal injury in glaucoma. The change to a reactive phenotype initiates signaling cascades that may serve a neuroprotective role, but may also proceed to promote damaging effects on retinal neurons. Both effects appear to occur most likely in parallel in glaucoma, but the underlying mechanisms and signaling pathways that specifically promote protective versus destructive roles of reactive glial cells are mostly unclear. More research is needed to understand the homeostatic signaling network in which retinal glia cells are embedded to maintain or restore neuronal function after injury.
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页码：339 / 345
页数：6
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