Enhancing myogenic differentiation of pluripotent stem cells with small molecule inducers

被引：0
作者：
Jihong Chen
Qiao Li
机构：
[1] University of Ottawa,Department of Cellular and Molecular Medicine, Faculty of Medicine
[2] University of Ottawa,Department of Pathology and Laboratory Medicine, Faculty of Medicine
来源：
Cell & Bioscience | / 3卷
关键词：
Stem cells; Myogenic differentiation; Histone acetylation; Gene regulation; Nuclear receptor;
D O I：
暂无
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摘要：
Pluripotent stem cells are able to differentiate into many types of cell lineages in response to differentiation cues. However, a pure population of lineage-specific cells is desirable for any potential clinical application. Therefore, induction of the pluripotent stem cells with lineage-specific regulatory signals, or small molecule inducers, is a prerequisite for effectively directing lineage specification for cell-based therapeutics. In this article, we provide in-depth analysis of recent research findings on small molecule inducers of the skeletal muscle lineage. We also provide perspectives on how different signaling pathways and chromatin dynamics converge to direct the differentiation of skeletal myocytes.
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