Metabolic control analysis and threshold effect in oxidative phosphorylation: Implications for mitochondrial pathologies

被引：0
作者：
T. Letellier
F. Bédes
M. Malgat
B. Korzeniewski
L.S. Jouaville
Ramuné Morkuniene
机构：
[1] Université de Bordeaux II,Institute of Molecular Biology
[2] Jagiellonian University,undefined
来源：
Molecular and Cellular Biochemistry | 1997年 / 174卷
关键词：
oxidative phosphorylation; metabolic control analysis (MCA); mitochondrial diseases; threshold effect;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
We have shown that the Metabolic Control Analysis (MCA) can explain the threshold effect observed in the expression of mitochondrial diseases [8]. As a matter of fact, the effect of a specific inhibitor on the flux of O2 consumption mimics a defect in a step of oxidative phosphorylation. The observed threshold is correlated to the value of the control coefficient of the inhibited step.
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页码：143 / 148
页数：5
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