Analysis of a polymorphism in the tuberous sclerosis (TSC2) gene does not predispose to schizophrenia

被引：0

作者：

Rene Przkora

P. Falkai

Andreas von Deimling

Otmar D. Wiestler

Margot Albus

Marcella Rietschel

Wolfgang Maier

Thomas A. Bayer

机构：

[1] Department of Neuropathology,

[2] University of Bonn Medical Center,undefined

[3] Sigmund-Freud-Strasse 25,undefined

[4] D-53105 Bonn,undefined

[5] Germany,undefined

[6] Department of Psychiatry,undefined

[7] University of Bonn Medical Center,undefined

[8] Sigmund-Freud-Strasse 25,undefined

[9] D-53105 Bonn,undefined

[10] Germany,undefined

[11] State Mental Hospital Haar,undefined

[12] Vockestrasse 72,undefined

[13] D-85540 Haar,undefined

[14] Germany,undefined

来源：

European Archives of Psychiatry and Clinical Neuroscience | 1998年 / 248卷

关键词：

Key words Schizophrenia; SSCP; TSC2;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The tuberous sclerosis complex (TSC) is an autosomal dominant disorder characterized by the development of malformations in various organs including the brain. A polymorphism in the TSC2 gene has been found to be increased in gangliogliomas, a lesion which is associated with disturbed neuro-glial cell migration pattern. Since these pathomorphological changes are compatible with disturbed neuronal migration in schizophrenic brains, we investigated this polymorphism in 130 families with a schizophrenic index patient. A 222-bp fragment of genomic DNA containing the TSC2 variant was analyzed by SSCP. The analysis revealed that there is no association with schizophrenia.

引用

页码：314 / 315

页数：1