HIF-1 inhibitors as anti-cancer therapy

被引：0
作者：
Suazette Reid Mooring
BingHe Wang
机构：
[1] Georgia State University,Department of Chemistry and Center for Biotechnology and Drug Design
来源：
Science China Chemistry | 2011年 / 54卷
关键词：
HIF-1; hypoxia; cancer therapy;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Hypoxia is a hallmark of solid tumors. Hypoxia increases the progression of malignancy and metastasis by promoting angiogenesis and triggering the over-expression of various protein products critical for tumor growth. The transcription factor HIF-1 mediates cellular response to hypoxia by promoting processes, such as glycolysis and angiogenesis. Clinical evidence has demonstrated that expression of HIF-1 is strongly associated with poor patient prognosis and activation of HIF-1 contributes to malignant behavior and therapeutic resistance. Therefore, HIF-1 is a viable target for cancer therapy. This review summarizes agents that have been described in the literature as HIF-1 inhibitors. The majority of these compounds are indirect inhibitors of HIF-1.
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页码：24 / 30
页数：6
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[21]  
Kaluzova M.(2002)Heat induction of the unphosphorylated form of hypoxia-inducible factor-1 alpha is dependent on heat shock protein-90 activity J Bio Chem 277 9262-9267
[22]  
Stanbridge E.J.(2002)Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway J Bio Chem 277 29936-29944
[23]  
Ohh M.(2004)PI3K/Akt is required for heat shock proteins to protect hypoxia-inducible factor 1 alpha from pVHL-independent degradation J Bio Chem 279 13506-13513
[24]  
Park C.W.(2000)Modulation of Akt kinase activity by binding to Hsp90 Proc Natl Acad Sci USA 97 10832-10837
[25]  
Ivan M.(2004)Synthesis and biological activities of novel 17-aminogeldanamycin derivatives Bioorg Med Chem 12 5317-5329
[26]  
Hoffman M.A.(1994)Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation Proc Natl Acad Sci USA 91 8324-8328
[27]  
Kim T.Y.(2003)The heat shock protein 90-targeting drug cisplatin selectively inhibits steroid receptor activation Mol Endocrinol 17 1991-2001
[28]  
Huang L.E.(2003)NMR chemical shift perturbation study of the N-terminal domain of Hsp90 upon binding of ADP, AMP-PNP, geldanamycin, and radicicol ChemBioChem 4 870-877
[29]  
Pavletich N.(1996)Functional interference between hypoxia and dioxin signal transduction pathways: Competition for recruitment of the Arnt transcription factor Mol Cell Biol 16 5221-5231
[30]  
Chau V.(2002)Geldanamycin induces degradation of hypoxia-inducible factor 1alpha protein via the proteosome pathway in prostate cancer cells Cancer Res 62 2478-2482
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