Three new sterigmatocystin analogues from marine-derived fungus Aspergillus versicolor MF359

被引：0
作者：
Fuhang Song
Biao Ren
Caixia Chen
Ke Yu
Xinru Liu
Yuhan Zhang
Na Yang
Hongtao He
Xueting Liu
Huanqin Dai
Lixin Zhang
机构：
[1] Institute of Microbiology,Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology
[2] University of Chinese Academy of Sciences,undefined
来源：
Applied Microbiology and Biotechnology | 2014年 / 98卷
关键词：
Marine-derived fungus; Sterigmatocystin;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
During the systematic screening of active compounds from marine-derived fungi, the extract of a strain of Aspergillus versicolor MF359 isolated from a marine sponge of Hymeniacidon perleve was identified for detailed chemical investigation. Three new secondary metabolites, named hemiacetal sterigmatocystin (1), acyl-hemiacetal sterigmatocystin (2), and 5-methoxydihydrosterigmatocystin (3), together with a known compound, aversin (4), were characterized. 1 represents a first structure of sterigmatocystin hemiacetal from nature. The antibacterial activities of these identified compounds were evaluated against Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, Bacillus subtilis, and Pseudomonas aeruginosa. Compound 3 showed activity against S. aureus and B. subtilis with MIC values of 12.5 and 3.125 μg/mL, respectively.
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页码：3753 / 3758
页数：5
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