Drug Insight: clinical use of agonists and antagonists of luteinizing-hormone-releasing hormone

被引：0

作者：

Jörg B Engel

Andrew V Schally

机构：

[1] Würzburg,JB Engel is affiliated with the Medical University of Würzburg Department of Obstetrics and Gynecology

[2] Germany.,Distinguished Medical Research Scientist of the Veterans Affairs Department

[3] AV Schally is Chief of the new Endocrine,undefined

[4] Polypeptide and Cancer Institute at the Veterans Administration Medical Center in Miami,undefined

[5] and Professor at the University of Miami,undefined

[6] Miller School of Medicine,undefined

[7] Miami,undefined

[8] FL,undefined

[9] USA.,undefined

来源：

Nature Clinical Practice Endocrinology & Metabolism | 2007年 / 3卷

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学科分类号：

摘要：

Both agonists and antagonists of luteinizing-hormone-releasing hormone (LHRH) are in clinical use for a wide range of cancers, benign prostatic hypertrophy, fibroids and reproductive disorders. This article describes the existing applications, those under investigation, and potential applications for this type of drug to target diseases such as Alzheimer's.

引用

页码：157 / 167

页数：10

共 94 条

[51]

Klijn JG(1998)The effect of nafarelin acetate, a luteinizing-hormone-releasing hormone agonist, on benign prostatic hyperplasia Regul Pept 77 185-24

[52]

Klijn JG(1986)Responses to the antagonistic analog of LH-RH (SB-75, cetrorelix) in patients with benign prostatic hyperplasia and prostatic cancer Lancet 2 1213-546

[53]

Forward DP(1987)Efficacy and safety of luteinizing hormone-releasing hormone antagonist cetrorelix in the treatment of symptomatic benign prostatic hyperplasia Fertil Steril 48 383-389

[54]

Jonat W(1989)Luteinizing hormone-releasing hormone (LH-RH) antagonist cetrorelix inhibits growth of DU-145 human androgen-independent prostate carcinoma in nude mice and suppresses the levels and mRNA expression of IGF-II in tumors Int J Fertil 34 19-1108

[55]

Jakesz R(2001)Rapid reduction of uterine myomas after short-term treatment with microencapsulated Fertil Steril 74 540-646

[56]

Sverrisdottir A(1999)-Trp6-LHRH Gynecol Endocrinol 13 382-2035

[57]

Bianco A(2002)Treatment of leiomyomata uteri with BJOG 109 1097-14

[58]

Davidson N(1993)-Trp6-luteinizing hormone-releasing hormone Fertil Steril 60 642-1083

[59]

McGuire WP(1997)Long-term use of an LH-RH agonist in the management of uterine leiomyomas: a study of 17 cases Hum Reprod 12 2028-745

[60]

Ozols RF(2001)Intermittent leuprolide acetate for the nonsurgical management of women with leiomyomata uteri Reprod Biomed Online 3 8-908

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