Drug Insight: clinical use of agonists and antagonists of luteinizing-hormone-releasing hormone

被引:0
作者
Jörg B Engel
Andrew V Schally
机构
[1] Würzburg,JB Engel is affiliated with the Medical University of Würzburg Department of Obstetrics and Gynecology
[2] Germany.,Distinguished Medical Research Scientist of the Veterans Affairs Department
[3] AV Schally is Chief of the new Endocrine,undefined
[4] Polypeptide and Cancer Institute at the Veterans Administration Medical Center in Miami,undefined
[5] and Professor at the University of Miami,undefined
[6] Miller School of Medicine,undefined
[7] Miami,undefined
[8] FL,undefined
[9] USA.,undefined
来源
Nature Clinical Practice Endocrinology & Metabolism | 2007年 / 3卷
关键词
D O I
暂无
中图分类号
学科分类号
摘要
Both agonists and antagonists of luteinizing-hormone-releasing hormone (LHRH) are in clinical use for a wide range of cancers, benign prostatic hypertrophy, fibroids and reproductive disorders. This article describes the existing applications, those under investigation, and potential applications for this type of drug to target diseases such as Alzheimer's.
引用
收藏
页码:157 / 167
页数:10
相关论文
共 94 条
[1]  
Matsuo H(1971)Structure of the porcine LH- and FSH-releasing hormone. I. The proposed amino acid sequence Biochem Biophys Res Commun 43 1334-1339
[2]  
Schally A. V.(1971)Gonadotropin-Releasing Hormone: One Polypeptide Regulates Secretion of Luteinizing and Follicle-Stimulating Hormones Science 173 1036-1038
[3]  
Arimura A.(1971)Hypothalamic follicle-stimulating hormone (FSH) and luteinizing hormone (LH)-regulating hormone: structure, physiology, and clinical studies Fertil Steril 22 703-721
[4]  
Kastin A. J.(1999)Luteinizing hormone-releasing hormone analogs: their impact on the control of tumorigenesis Peptides 20 1247-1262
[5]  
Matsuo H.(1998)Second gene for gonadotropin-releasing hormone in humans Proc Natl Acad Sci USA 95 305-309
[6]  
Baba Y.(2004)Human type II receptor mediates effects of GnRH on cell proliferation Zoolog Sci 21 763-770
[7]  
Redding T. W.(2001)Hypothalamic hormones and cancer Front Neuroendocrinol 22 248-291
[8]  
Nair R. M. G.(1994)The use of luteinizing hormone releasing hormone agonists and antagonists in gynecological cancers Hum Reprod 9 1364-1379
[9]  
Debeljuk L.(2002)The gonadotrophin-releasing hormone receptor: signaling, cycling and desensitisation Arch Physiol Biochem 110 113-122
[10]  
White W. F.(2003)Phase II study of abarelix depot for androgen independent prostate cancer progression during gonadotropic-releasing hormone agonist therapy J Urol 169 1738-1741