Efficacy and Safety of Ixekizumab Through 5 Years in Moderate-to-Severe Psoriasis: Long-Term Results from the UNCOVER-1 and UNCOVER-2 Phase-3 Randomized Controlled Trials

被引:0
|
作者
Craig Leonardi
Kristian Reich
Peter Foley
Hideshi Torii
Sascha Gerdes
Lyn Guenther
Melinda Gooderham
Laura K. Ferris
Christopher E. M. Griffiths
Hany ElMaraghy
Heidi Crane
Himanshu Patel
Russel Burge
Gaia Gallo
David Shrom
Ann Leung
Chen-Yen Lin
Kim Papp
机构
[1] Central Dermatology,Center for Translational Research in Inflammatory Skin Diseases, Institute for Health Services Research in Dermatology and Nursing
[2] University Medical Center Hamburg-Eppendorf,St. Vincent’s Hospital Melbourne and Probity Medical Research, Skin Health Institute
[3] Skinflammation® Center,Division of Dermatology
[4] The University of Melbourne,Psoriasis
[5] Tokyo Yamate Medical Center,Center at the Department of Dermatology
[6] University Medical Center Schleswig-Holstein,Dermatology Centre, Salford Royal Hospital
[7] Guenther Dermatology Research Centre,undefined
[8] SkiN Centre for Dermatology and Probity Medical Research,undefined
[9] University of Pittsburgh Medical Center,undefined
[10] University of Manchester,undefined
[11] Eli Lilly and Company,undefined
[12] Lilly Corporate Center,undefined
[13] Syneos Health,undefined
[14] K. Papp Clinical Research and Probity Medical Research Inc.,undefined
来源
Dermatology and Therapy | 2020年 / 10卷
关键词
Ixekizumab; Long-term efficacy; Long-term safety; Maintain; Psoriasis; Quality of life; 5 years;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:431 / 447
页数:16
相关论文
共 50 条
  • [1] Efficacy and Safety of Ixekizumab Through 5 Years in Moderate-to-Severe Psoriasis: Long-Term Results from the UNCOVER-1 and UNCOVER-2 Phase-3 Randomized Controlled Trials
    Leonardi, Craig
    Reich, Kristian
    Foley, Peter
    Torii, Hideshi
    Gerdes, Sascha
    Guenther, Lyn
    Gooderham, Melinda
    Ferris, Laura K.
    Griffiths, Christopher E. M.
    ElMaraghy, Hany
    Crane, Heidi
    Patel, Himanshu
    Burge, Russel
    Gallo, Gaia
    Shrom, David
    Leung, Ann
    Lin, Chen-Yen
    Papp, Kim
    DERMATOLOGY AND THERAPY, 2020, 10 (03) : 431 - 447
  • [2] Sustained response with ixekizumab treatment of moderate-to-severe psoriasis with scalp involvement: results from three phase 3 trials (UNCOVER-1, UNCOVER-2, UNCOVER-3)
    Reich, Kristian
    Leonardi, Craig
    Lebwohl, Mark
    Kerdel, Francisco
    Okubo, Yukari
    Romiti, Ricardo
    Goldblum, Orin
    Dennehy, Ellen B.
    Kerr, Lisa
    Sofen, Howard
    JOURNAL OF DERMATOLOGICAL TREATMENT, 2017, 28 (04) : 282 - 287
  • [3] Ixekizumab treatment shows a neutral impact on cardiovascular parameters in patients with moderate-to-severe plaque psoriasis: Results from UNCOVER-1, UNCOVER-2, and UNCOVER-3
    Egeberg, Alexander
    Wu, Jashin J.
    Korman, Neil
    Solomon, James A.
    Goldblum, Orin
    Zhao, Fangyi
    Mallbris, Lotus
    JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2018, 79 (01) : 104 - +
  • [4] Comparison of ixekizumab with etanercept or placebo in moderate-to-severe psoriasis (UNCOVER-2 and UNCOVER-3): results from two phase 3 randomised trials
    Griffiths, Christopher E. M.
    Reich, Kristian
    Lebwohl, Mark
    van de Kerkhof, Peter
    Paul, Carle
    Menter, Alan
    Cameron, Gregory S.
    Erickson, Janelle
    Zhang, Lu
    Secrest, Roberta J.
    Ball, Susan
    Braun, Daniel K.
    Osuntokun, Olawale O.
    Heffernan, Michael P.
    Nickoloff, Brian J.
    Papp, Kim
    LANCET, 2015, 386 (9993): : 541 - 551
  • [5] Efficacy and safety of ixekizumab treatment in Japanese patients with moderate-to-severe plaque psoriasis: Subgroup analysis of a placebo-controlled, phase 3 study (UNCOVER-1)
    Imafuku, Shinichi
    Torisu-Itakura, Hitoe
    Nishikawa, Atsushi
    Zhao, Fangyi
    Cameron, Gregory S.
    JOURNAL OF DERMATOLOGY, 2017, 44 (11): : 1285 - 1290
  • [6] Efficacy and safety of ixekizumab for the treatment of moderate-to-severe plaque psoriasis: Results through 108 weeks of a randomized, controlled phase 3 clinical trial (UNCOVER-3)
    Blauvelt, Andrew
    Gooderham, Melinda
    Iversen, Lars
    Ball, Susan
    Zhang, Lu
    Agada, Noah O.
    Reich, Kristian
    JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2017, 77 (05) : 855 - 862
  • [7] Ixekizumab impact on the skin-related relationship problems of patients with moderate-to-severe plaque psoriasis: integrated results from three Phase 3 trials (UNCOVER-1,-2,-3)
    Warren, R. B.
    Cather, J.
    Ohtsuki, M.
    Bleakman, A. Potts
    Burge, R.
    Zhu, B.
    Reich, K.
    JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2016, 30 : 77 - 78
  • [8] Sustained High Efficacy and Favorable Safety Over Five Years in Patients With Burdensome Psoriasis (UNCOVER-1/UNCOVER-2)
    Papp, Kim A.
    Gerdes, Sascha
    Leonardi, Craig L.
    Elmaraghy, Hany
    See, Kyoungah
    McKean-Matthews, Missy
    Konicek, Bruce W.
    Crane, Heidi M.
    Eastman, William
    JOURNAL OF DRUGS IN DERMATOLOGY, 2021, 20 (08) : 880 - 887
  • [9] Efficacy and safety of ixekizumab in patients with plaque psoriasis across different degrees of disease severity: results from UNCOVER-2 and UNCOVER-3
    Kemeny, Lajos
    Berggren, Lovisa
    Dossenbach, Martin
    Dutronc, Yves
    Paul, Carle
    JOURNAL OF DERMATOLOGICAL TREATMENT, 2019, 30 (01) : 19 - 26
  • [10] Absolute and Relative Psoriasis Area and Severity Indices (PASI) for Comparison of the Efficacy of Ixekizumab to Etanercept and Placebo in Patients with Moderate-to-severe Plaque Psoriasis: An Integrated Analysis of UNCOVER-2 and UNCOVER-3 Outcomes
    Puig, Luis
    Dossenbach, Martin
    Berggren, Lovisa
    Ljungberg, Anders
    Zachariae, Claus
    ACTA DERMATO-VENEREOLOGICA, 2019, 99 (11) : 971 - 977