Anti-inflammatory, antioxidant and hepatoprotective effects of Thunbergia laurifolia Linn. on experimental opisthorchiasis

被引:0
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作者
Orasa Wonkchalee
Thidarut Boonmars
Chantana Aromdee
Porntip Laummaunwai
Watcharee Khunkitti
Kulthida Vaeteewoottacharn
Pranee Sriraj
Ratchadawan Aukkanimart
Watchalin Loilome
Yaovaluk Chamgramol
Chawalit Pairojkul
Zhiliang Wu
Amornrat Juasook
Pakkayanee Sudsarn
机构
[1] Faculty of Medicine,Department of Parasitology
[2] Khon Kaen University,Liver Fluke and Cholangiocarcinoma Research Center
[3] Faculty of Medicine,Faculty of Pharmacology
[4] Khon Kaen University,Department of Biochemistry
[5] Khon Kaen University,Department of Parasitology
[6] Faculty of Medicine,Department of Pathology
[7] Khon Kaen University,undefined
[8] Gifu University Medicine,undefined
[9] Graduate School,undefined
[10] Faculty of Medicine,undefined
[11] Khon Kaen University,undefined
来源
Parasitology Research | 2012年 / 111卷
关键词
Bile Duct; Blood Urea Nitrogen; Apigenin; Total Antioxidant Capacity; Syrian Hamster;
D O I
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学科分类号
摘要
Thunbergia laurifolia Linn (Rang Chuet) possesses antioxidant and anti-inflammatory properties as well as anticancer activities. The aim of the present study was to evaluate the efficacy of T. laurifolia in reducing inflammation from pathological changes in Syrian hamsters infected with the human liver fluke Opisthorchis viverrini. Hamster groups were also administered N-nitrosodimethylamine (NDMA) and treated with T. laurifolia. Light microscopic observation of histopathological changes, liver function tests for alanine transaminase (ALT) and alkaline phosphatase (ALP) and kidney function tests for blood urea nitrogen (BUN) and creatinine were performed. Antioxidant effects of both fresh and dried Rang Chuet solutions were observed. Analysis of the histopathological changes showed anti-inflammatory properties, both in the case of O. viverrini infection or with NDMA administration, by reducing the aggregation of inflammatory cells surrounding the hepatic bile ducts as indicated by normal serum ALT, ALP, BUN and creatinine levels in treated Syrian hamsters. The present study found that fresh and dried Rang Chuet solutions clearly reduced the inflammatory cells in both O. viverrini-infected and NDMA-administered groups and was correlated with the total antioxidant capacity. These findings suggest that T. laurifolia possesses antioxidant and anti-inflammatory properties and that its application may be useful for prevention of the inflammatory process, one of the risk factors of O. viverrini-associated cholangiocarcinoma (CCA).
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页码:353 / 359
页数:6
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