Robotic-assisted radical prostatectomy is less stressful than the open approach: results of a contemporary prospective study evaluating pathophysiology of cortisol stress-related kinetics in prostate cancer surgery

被引：11

作者：

Porcaro A.B. ^{[1
,4
]}

Molinari A. ^{[1
]}

Terrin A. ^{[1
]}

De Luyk N. ^{[1
]}

Baldassarre R. ^{[1
]}

Brunelli M. ^{[2
]}

Cavalleri S. ^{[1
]}

Cerruto M.A. ^{[1
]}

Gelati M. ^{[2
]}

Salvagno G.L. ^{[3
]}

Guidi G.C. ^{[3
]}

Artibani W. ^{[1
]}

机构：

[1] Urologic Clinic, University Hospital, Ospedale Policlinico, Azienda Ospedaliera Universitaria Integrata, Verona

[2] Department of Pathology, University Hospital, Ospedale Policlinico, Azienda Ospedaliera Universitaria Integrata, Verona

[3] Department of Laboratory Medicine, University Hospital, Ospedale Policlinico, Azienda Ospedaliera Universitaria Integrata, Verona

[4] Divisione Clinicizzata Di Urologia, Dipartimento ad Attività Integrata di Chirurgia e Oncologia, Pancreas Center, Azienda Ospedaliera Universitaria Integrata Verona, Policlinico GB Rossi-P.le LA Scuro, 10, Verona

来源：

Journal of Robotic Surgery | 2015年 / 9卷 / 3期

关键词：

Cortisol hormone; Prostate cancer; Retropubic radical prostatectomy; Robot-assisted radical prostatectomy; Stress system;

D O I：

10.1007/s11701-015-0522-3

中图分类号：

学科分类号：

摘要：

The objective of this study was to investigate the effects of prostate cancer (PCA) surgery on the stress system and to identify potential independent factors associating with stress recovery. The design of the study was prospective and PCA surgery included robot-assisted radical prostatectomy (RARP) or retro pubic radical prostatectomy. Between February and December 2013, 151 consecutive patients were evaluated. The effects of PCA surgery on the stress system were measured by cortisol serum levels before and after surgery on post-operative day (POD) 0, 1, 3, 5 and 45. Statistical methods were applied. RARP was performed in 71 % of cases. PCA surgery triggered the stress system which immediately (POD 0) responded by cortisol overproduction which induced the negative feedback mechanism that started on POD 1, continued on POD. © 2015, Springer-Verlag London.

引用

页码：249 / 255

页数：6

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