Iron deficiency or anemia of inflammation?: Differential diagnosis and mechanisms of anemia of inflammation; [Eisenmangel oder Entzündungsanämie?: Differenzialdiagnose und Mechanismen der Entzündungsanämie]

被引：92
作者：
Nairz M. [1 ]
Theurl I. [1 ]
Wolf D. [2 ]
Weiss G. [1 ]
机构：
[1] Department of Internal Medicine VI, Infectious Diseases, Immunology, Rheumatology, Pneumology, Medical University of Innsbruck, Anichstraße 35, Innsbruck
[2] Medical Clinic III, Department of Oncology, Hematology and Rheumatology, University Clinic Bonn (UKB), Bonn
来源：
Wiener Medizinische Wochenschrift | 2016年 / 166卷 / 13-14期
关键词：
Anemia of chronic disease; Anemia of inflammation; Hepcidin; Iron; Macrophage;
D O I：
10.1007/s10354-016-0505-7
中图分类号：
学科分类号：
摘要：
Iron deficiency and immune activation are the two most frequent causes of anemia, both of which are based on disturbances of iron homeostasis. Iron deficiency anemia results from a reduction of the body’s iron content due to blood loss, inadequate dietary iron intake, its malabsorption, or increased iron demand. Immune activation drives a diversion of iron fluxes from the erythropoietic bone marrow, where hemoglobinization takes place, to storage sites, particularly the mononuclear phagocytes system in liver and spleen. This results in iron-limited erythropoiesis and anemia. This review summarizes current diagnostic and pathophysiological concepts of iron deficiency anemia and anemia of inflammation, as well as combined conditions, and provides a brief outlook on novel therapeutic options. © 2016, The Author(s).
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页码：411 / 423
页数：12
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