Medial septum differentially regulates dopamine neuron activity in the rat ventral tegmental area and substantia nigra via distinct pathways

被引：0
作者：
David M. Bortz
Anthony A. Grace
机构：
[1] University of Pittsburgh,Departments of Neuroscience, Psychiatry, and Psychology
来源：
Neuropsychopharmacology | 2018年 / 43卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The medial septum (MS) impacts hippocampal activity and the hippocampus, in turn, regulates midbrain dopamine (DA) neuron activity. However, it remains to be determined how MS activation impacts midbrain DA activity. This question was addressed by infusing NMDA (0.75 µg/0.2 µL) into the medial septum of anesthetized male Sprague-Dawley rats and recording dopamine neuron activity in the ventral tegmental area (VTA) and substantia nigra pars compacta (SNc). MS activation increased (71%) the number of spontaneously active DA neurons in the VTA, and decreased (40%) the number of active DA neurons in the SNc. Effects in both the VTA and SNc required the ventral subiculum, but were differentially dependent on cholinergic and GABAergic mechanisms within the vSub and rostral and caudal subregions of the ventral pallidum, respectively. MS activation also decreased amphetamine-induced locomotor behavior, which was dependent on GABAergic inputs to the hippocampus. These findings demonstrate that the MS differentially regulates meso-striatal DA transmission via distinct pathways.
引用
收藏
页码：2093 / 2100
页数：7
相关论文
共 150 条
  • [1] Berridge KC(1998)What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? Brain Res Brain Res Rev 28 309-69
  • [2] Robinson TE(2003)Description of Parkinson’s disease as a clinical syndrome Ann NY Acad Sci 991 1-14
  • [3] Fahn S(2016)Dysregulation of the dopamine system in the pathophysiology of schizophrenia and depression Nat Rev Neurosci 17 524-32
  • [4] Grace AA(2015)The dopamine theory of addiction: 40 years of highs and lows Nat Rev Neurosci 16 305-12
  • [5] Nutt DJ(2001)Glutamatergic afferents from the hippocampus to the nucleus accumbens regulate activity of ventral tegmental area dopamine neurons J Neurosci 21 4915-22
  • [6] Lingford-Hughes A(2003)Afferent modulation of dopamine neuron firing differentially regulates tonic and phasic dopamine transmission Nat Neurosci 6 968-73
  • [7] Erritzoe D(2006)The hippocampus modulates dopamine neuron responsivity by regulating the intensity of phasic neuron activation Neuropsychopharmacology 31 1356-61
  • [8] Stokes PR(2011)Projection-specific modulation of dopamine neuron synapses by aversive and rewarding stimuli Neuron 70 855-62
  • [9] Floresco SB(1998)The phasic reward signal of primate dopamine neurons Adv Pharmacol 42 686-90
  • [10] Todd CL(2003)Distinct electrophysiological properties of glutamatergic, cholinergic and GABAergic rat septohippocampal neurons: novel implications for hippocampal rhythmicity J Physiol 551 927-43
12345678910