DNA hydrogels formed of bended DNA scaffolds and properties study

被引：0
作者：
Hao-yang Jia
Jie-zhong Shi
Yu Shao
Dong-sheng Liu
机构：
[1] Tsinghua University,Key Laboratory of Organic Optoelectronics & Molecular Engineering of the Ministry of Education, Department of Chemistry
来源：
Chinese Journal of Polymer Science | 2017年 / 35卷
关键词：
Linear DNA; Hydrogel; Bended structures;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
In recent years, DNA supramolecular hydrogels have attracted much attention due to their injectability, biocompatibility, responsiveness and self-healing properties. In this work, we designed a linear DNA brick containing one duplex with two cytosine (C)-rich sequence on both ends. This brick can first assemble to form duplex under pH 8 condition. After adjusting the pH to 5, the C-rich sequence tends to form intermolecular i-motif structure, which joins the linear DNA molecules together to form interlocked cyclic structures and yield the DNA hydrogel. By adjusting the length and bending curvature of the duplex part of the molecule, one can change the basic unit of the hydrogel structure to tune the properties of the DNA hydrogel.
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页码：1307 / 1314
页数：7
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