Accurate macromolecular structures using minimal measurements from X-ray free-electron lasers

被引：0

作者：

Hattne J. ^{[1
]}

Echols N. ^{[1
]}

Tran R. ^{[1
]}

Kern J. ^{[1
]}

Gildea R.J. ^{[1
,10
]}

Brewster A.S. ^{[1
]}

Alonso-Mori R. ^{[2
]}

Glöckner C. ^{[3
]}

Hellmich J. ^{[3
]}

Laksmono H. ^{[4
]}

Sierra R.G. ^{[4
]}

Lassalle-Kaiser B. ^{[1
]}

Lampe A. ^{[1
]}

Han G. ^{[1
]}

Gul S. ^{[1
]}

Difiore D. ^{[3
]}

Milathianaki D. ^{[2
]}

Fry A.R. ^{[2
]}

Miahnahri A. ^{[2
]}

White W.E. ^{[2
]}

Schafer D.W. ^{[2
]}

Seibert M.M. ^{[2
]}

Koglin J.E. ^{[2
]}

Sokaras D. ^{[5
]}

Weng T.-C. ^{[5
]}

Sellberg J. ^{[5
,6
]}

Latimer M.J. ^{[5
]}

Glatzel P. ^{[7
]}

Zwart P.H. ^{[1
]}

Grosse-Kunstleve R.W. ^{[1
]}

Bogan M.J. ^{[2
,4
]}

Messerschmidt M. ^{[2
]}

Williams G.J. ^{[2
]}

Boutet S. ^{[2
]}

Messinger J. ^{[8
]}

Zouni A. ^{[3
,9
]}

Yano J. ^{[1
]}

Bergmann U. ^{[2
]}

Yachandra V.K. ^{[1
]}

Adams P.D. ^{[1
]}

Sauter N.K. ^{[1
]}

机构：

[1] Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA

[2] Linac Coherent Light Source (LCLS), SLAC National Accelerator Laboratory, Menlo Park, CA

[3] Max-Volmer-Laboratorium für Biophysikalische Chemie, Technische Universität, Berlin

[4] Stanford PULSE Institute, SLAC National Accelerator Laboratory, Menlo Park, CA

[5] Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, CA

[6] Department of Physics, AlbaNova, Stockholm University, Stockholm

[7] European Synchrotron Radiation Facility, Grenoble

[8] Institutionen för Kemi, Kemiskt Biologiskt Centrum, Umeå Universitet, Umeå

[9] Institut für Biologie, Humboldt Universität zu Berlin, Berlin

[10] Diamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxfordshire

来源：

Nature Methods | 2014年 / 11卷 / 5期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nmeth.2887

中图分类号：

学科分类号：

摘要：

X-ray free-electron laser (XFEL) sources enable the use of crystallography to solve three-dimensional macromolecular structures under native conditions and without radiation damage. Results to date, however, have been limited by the challenge of deriving accurate Bragg intensities from a heterogeneous population of microcrystals, while at the same time modeling the X-ray spectrum and detector geometry. Here we present a computational approach designed to extract meaningful high-resolution signals from fewer diffraction measurements. © 2014 Nature America, Inc.

引用

页码：545 / 548

页数：3

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