The Impact of High-dose Sodium Selenite Therapy on Bcl-2 Expression in Adult Non-Hodgkin’s Lymphoma Patients: Correlation with Response and Survival

被引：0
作者：
Inas A. Asfour
Manal Fayek
Soha Raouf
Marize Soliman
Hany M. Hegab
Hosam El-Desoky
Rehab Saleh
Mohamed A. R. Moussa
机构：
[1] Ain Shams University Hospital,Clinical Hematology and Bone Marrow Transplantation Unit, Department of Internal Medicine
[2] Ain Shams University,Department of Clinical Pathology, Faculty of Medicine
来源：
Biological Trace Element Research | 2007年 / 120卷
关键词：
Sodium selenite; Bcl-2; Non-Hodgkin’s lymphoma; Overall survival;
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摘要：
The present study was undertaken to explore the effect of administration of high doses of sodium selenite on the expression of Bcl-2 in patients with non-Hodgkin’s lymphoma (NHL). Fifty patients with newly diagnosed NHL were randomly divided into two groups. Group A-I received standard chemotherapy whereas group A-II received adjuvant sodium selenite 0.2 mg kg−1 day−1 for 30 days in addition to chemotherapy. Enzyme-linked immunosorbent assay was used to assess Bcl-2 at the time of diagnosis and after therapy in the two groups. Sodium selenite administration resulted in significant decline of Bcl-2 level after therapy in group A-II (8.6 ± 6.9 ng/ml vs 3 6.9 ± 7.9 ng/ml, P < 0.05). Also, complete response reached 60% in group A-II compared to 40% in group A-I. Significant increase in CD4/CD8 ratio was noticed in group A-II compared to group A-I after therapy (1.45 ± 0.36 vs 1.10 ± 0.28 p 0.04). Overall survival time in months was significantly longer in complete remission patients in group A-II (21.87 ± 1.41) compared to group A-I (19.70 ± 1.95) (p = 0.01). It is concluded that sodium selenite administration at the dosage and duration chosen acts as a downregulator of Bcl-2 and improves clinical outcome.
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页码：1 / 10
页数：9
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  • [11] Engelhardt M(2004)Selenium biochemistry and cancer: a review of the literature Altern Med Rev 9 239-310
  • [12] Gisselbrecht C(2005)Impact of diet on prostate cancer: a review Prostate Cancer Prostatic Dis 8 304-542
  • [13] Mounier N(2005)Selenium in cancer prevention: a review of the evidence and mechanism of action Proc Nutr Soc 64 527-32
  • [14] Seymour JF(2006)Effect of high dose sodium selenite therapy on polymorphonuclear leucocyte apoptosis in non Hodgkin’s lymphoma patients Biol Trace Elem Res 110 19-294
  • [15] Adams JM(1991)A preliminary report on the intervention trials of primary liver cancer in high-risk populations with nutritional supplementation of selenium in China Biol Trace Elem Res 29 289-17
  • [16] Wei MC(1996)Bcl-2, a novel regulator for apoptosis J Cell Biochem 60 12-6534
  • [17] Combs GF(2004)The epidemiology of non-Hodgkin’s lymphoma Oncogene 23 6524-426
  • [18] Dhingra S(2002)Proteins encoded by genes involved in chromosomal alterations in lymphoma and leukemia: clinical value of their detection by immunocytochemistry Blood 99 409-8580
  • [19] Bansal MP(2003)The inhibitors of apoptosis: there is more to life than Bcl2 Oncogene 22 8568-272
  • [20] Beck MA(2004)What is new in lymphoma? CA Cancer J Clin 54 260-2902
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