Expression of TLR4-PTGE2 signaling genes in atherosclerotic carotid plaques and peripheral blood

被引：0
作者：
S. Ferronato
A. Scuro
S. Fochi
E. Orlandi
M. Gomez-Lira
S. Olivato
S. Mazzucco
A. Turco
M. G. Romanelli
机构：
[1] University of Verona,Section of Biology and Genetics, Department of Neurosciences, Biomedicine, and Movement Sciences
[2] University of Verona,Department of Surgery, Dentistry, Pediatrics and Gynaecology, Unit of Vascular and Endovascular Surgery
[3] University of Verona,Section of Neurophatology, Department of Neurosciences, Biomedicine, and Movement Sciences
[4] University of Oxford,Department of Clinical Neurosciences, Centre for Prevention of Stroke and Dementia Nuffield
来源：
Molecular Biology Reports | 2019年 / 46卷
关键词：
Gene expression; Blood and plaques; Atherosclerosis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Toll-like receptor 4 (TLR4)/prostaglandine synthetase 2 (PTGS2) signaling plays a relevant role in atherosclerotic plaque vulnerability. The purpose of this study was to check the gene expression of 6 genes participating to TLR4/PTGS2 signaling (TLR4, PTGS2, ACSL4, PTGER3, PTGER4, and EPRAP) in carotid plaques and blood samples from the same individual and to evaluate these genes as biomarker of plaque progression. We investigated differential gene expression by qRT-PCR in 62 atherosclerotic patients’ carotid plaques and corresponding blood sample. A very weak or no correlation was observed in the overall population or analyzing asymptomatic patients. These analyzed genes are most likely not suitable for inclusion in the clinical routine as biomarkers of plaque instability.
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页码：1317 / 1321
页数：4
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