Photoluminescent decoration of iron oxide magnetic nanoparticles for dual-imaging applications

被引：0

作者：

Antonio Palumbo Piccionello

Luca Menichetti

Paolo Armanetti

Alessandra Flori

Ilaria Monaco

Mirko Maturi

Andrea Pace

Erica Locatelli

机构：

[1] Università degli Studi di Palermo,Dipartimento di Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche. STEBICEF

[2] CNR Institute of Clinical Physiology,undefined

[3] CNR/Fondazione Toscana G. Monasterio,undefined

[4] Department of Industrial Chemistry “Toso Montanari”,undefined

来源：

Journal of Nanoparticle Research | 2018年 / 20卷

关键词：

Magnetic nanoparticles; Fluorescent nanoparticles; Dopamine; Dual-imaging; Drug delivery;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

A selective functionalization of dopamine amino group with the photoluminescent 7-nitroben-zofurazan was achieved through a one-pot protection-functionalization-deprotection sequence. The resulting fluorescent catecholic ligand was used as a capping agent for iron oxide nanoparticles thus obtaining photoluminescent magnetic nanoparticles (PL-MNPs). The PL-MNPs were then embedded into PLGA-b-PEG polymeric nanocarriers which quenched the emission of the capping agent. Full recovery of fluorescence was observed after disassembling the polymeric layer of the nanoparticle, thus supporting the use of PL-MNPs as a multifunctional system for targeted drug delivery.

引用

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