Citrullus lanatus methanol seed extract exhibits antioxidant and anti-inflammatory potential against ethanol-induced kidney damage in Wistar rats

被引：0

作者：

Bazabang S.A. ^{[1
]}

Makena W. ^{[2
]}

Rilwan H.B. ^{[3
]}

Onimisi O.B. ^{[4
]}

Buba H.S. ^{[2
]}

Jerome V.K. ^{[5
]}

机构：

[1] Department of Human Anatomy, Ahmadu Bello University, Kaduna State, Zaria

[2] Department of Human Anatomy, Faculty of Basic Medical Sciences, College of Medicine, University of Maiduguri, Borno State, Maiduguri

[3] Department of Human Anatomy, Kaduna State University, Kaduna State, Kaduna

[4] Department of Human Anatomy, Usmanu Danfodiyo University, Sokoto State, Sokoto

[5] Department of Human Physiology, Ahmadu Bello University, Kaduna State, Zaria

来源：

Comparative Clinical Pathology | 2023年 / 32卷 / 5期

关键词：

Antioxidant enzymes; Citrullus lanatus Ethanol; Inflammation; Kidney;

D O I：

10.1007/s00580-023-03479-w

中图分类号：

学科分类号：

摘要：

Ethanol consumption can generate free radicals and cause oxidative stress, tissue inflammation, and kidney impairment. It has long been known that saponins from natural sources have numerous therapeutic benefits in African herbal and traditional medicine. However, the study aimed to the study aimed to evaluate the ameliorative effect of saponin-rich extract of Citrullus lanatus seed against ethanol-induced kidney injury. Rats were divided into six groups: a normal control, an ethanol control (10 ml/kg of 50% ethanol), a saponin control (100 mg/kg/day), an ethanol plus low and high doses of saponin (ET + 50 and 100 mg/kg SCL), and an ethanol plus Silymarin (ET + 100 mg/kg SLY) group. Serum urea, creatinine, and uric acid were measured, as were oxidative stress markers and renal tissue inflammatory markers. The ethanol-induced increases in creatinine, urea, and uric acid were significantly (p < 0.05) mitigated by Citrullus lanatus seed saponins (SCL). When rats administered SCL were compared to untreated ethanol rats, CAT, SOD, and GPx levels increased significantly (p < 0.05), whereas MDA decreased. Likewise, SCL dramatically lowered IL-1β and TNF-α levels in ethanol-treated rats. A histopathological study strongly supported the result of the biochemical assay. The results of this study reveal that by reducing the rise in renal function, inflammatory markers, and oxidative stress, the saponin-rich fraction of Citrullus lanatus seed has therapeutic potential against ethanol-induced kidney damage. SCL may therefore act as a plant-based natural remedy to reduce kidney damage. © 2023, The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature.

引用

页码：733 / 742

页数：9

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