Minor secoiridoid aglycones from the low-polarity part of the traditional Chinese herb: Swertia mileensis

被引：20
作者：
Geng C.-A. [1 ]
Zhang X.-M. [1 ]
Ma Y.-B. [1 ]
Huang X.-Y. [1 ]
Chen J.-J. [1 ]
机构：
[1] State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming
来源：
Natural Products and Bioprospecting | 2013年 / 3卷 / 5期
关键词：
anti-HBV activity; secoiridoid aglycones; swerimilegenins; Swertia mileensis;
D O I：
10.1007/s13659-013-0059-y
中图分类号：
学科分类号：
摘要：
Eleven new secoiridoid aglycones involving unusual C9-skeleton: swerimilegenins A-F (1–6); bis-C9-skeleton: swerimilegenin G (7); and C10-skeleton: swerimilegenins H-K (8–11), as well as six known ones, were isolated from the low-polarity part of the traditional Chinese herb medicine Swertia mileensis. Their structures were determined by extensive spectroscopic data and X-ray diffraction. Biogenetically, swerimilegenin A (1) belonged to 10-nor-secoiridoid, and swerimilegenins B-F (2–6) were 1-nor-secoiridoids. Erythrocentaurin (12) and gentiogenal (15) showed moderate anti-HBV activity on HepG 2.2.15 cell line in vitro. [Figure not available: see fulltext.]. © 2013, The Author(s).
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页码：243 / 249
页数：6
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