Deficiency of 14-3-3ϵ and 14-3-3ζ by the Wnt1 promoter-driven Cre recombinase results in pigmentation defects

被引：7

作者：

Cornell B. ^{[1
]}

Toyo-Oka K. ^{[1
]}

机构：

[1] Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, 19129, PA

来源：

BMC Research Notes | / 9卷 / 1期

关键词：

14-3-3; Cre transgenic mouse; Knockout mouse; Melanocyte; Neural crest cell; Pigmentation; Weight modulation; White patch; Ywhae; Ywhaz;

D O I：

10.1186/s13104-016-1980-z

中图分类号：

学科分类号：

摘要：

Background: The seven 14-3-3 protein isoforms bind to numerous proteins and are involved in a wide variety of cellular events, including the cell cycle, cell division, apoptosis and cancer. We previously found the importance of 14-3-3 proteins in neuronal migration of pyramidal neurons in the developing cortex. Here, we test the function of 14-3-3 proteins in the development of neural crest cells in vivo using mouse genetic approaches. Results: We found that 14-3-3 proteins are important for the development of neural crest cells, in particular for the pigmentation of the fur on the ventral region of mice. Conclusions: Our data obtained from the 14-3-3ϵ/14-3-3ζ/Wnt1-Cre mice strongly indicate the importance of 14-3-3 proteins in the development of melanocyte lineages. © 2016 Cornell and Toyo-oka.

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