The Wilms’ tumour suppressor Wt1 is a major regulator of tumour angiogenesis and progression

被引：0

作者：

Kay-Dietrich Wagner

Julien Cherfils-Vicini

Naoki Hosen

Peter Hohenstein

Eric Gilson

Nicholas D. Hastie

Jean-François Michiels

Nicole Wagner

机构：

[1] Institute for Research on Cancer and Aging,Division of Health Sciences

[2] Nice (IRCAN),Department of Medical Genetics

[3] Faculty of Medicine,Department of Pathology

[4] University of Nice Sophia-Antipolis,undefined

[5] Osaka University Graduate School of Medicine,undefined

[6] The Roslin Institute,undefined

[7] University of Edinburgh,undefined

[8] Easter Bush Campus,undefined

[9] Midlothian EH25 9RG,undefined

[10] UK,undefined

[11] CHU Nice,undefined

[12] MRC Human Genetics Unit,undefined

[13] MRC Institute of Genetics and Molecular Medicine,undefined

[14] University of Edinburgh,undefined

[15] CHU Nice,undefined

来源：

Nature Communications | / 5卷

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摘要：

Angiogenesis, activation of metastasis and avoidance of immune destruction are important for cancer progression. These biological capabilities are, apart from cancer cells, mediated by different cell types, including endothelial, haematopoietic progenitor and myeloid-derived suppressor cells. We show here that all these cell types frequently express the Wilms’ tumour suppressor Wt1, which transcriptionally controls expression of Pecam-1 (CD31) and c-kit (CD117). Inducible conditional knockout of Wt1 in endothelial, haematopoietic and myeloid-derived suppressor cells is sufficient to cause regression of tumour vascularization and an enhanced immune response, leading to decreased metastasis, regression of established tumours and enhanced survival. Thus, Wt1 is an important regulator of cancer growth via modulation of tumour vascularization, immune response and metastasis formation.

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