Small extrachromosomal circular DNA harboring targeted tumor suppressor gene mutations supports intratumor heterogeneity in mouse liver cancer induced by multiplexed CRISPR/Cas9

被引:0
作者
Tao Guo
Guo-Qiao Chen
Xu-Fan Li
Meng Wang
Kun-Ming Liu
Xiao-Ying Yang
Si-Cheng Liu
Yi-Li Feng
Peng-Yuan Liu
Hui Lin
An-Yong Xie
机构
[1] Sir Run Run Shaw Hospital,Innovation Center for Minimally Invasive Technique and Device, Department of General Surgery
[2] Zhejiang University School of Medicine,undefined
[3] Institute of Translational Medicine,undefined
[4] Zhejiang University School of Medicine and Zhejiang University Cancer Center,undefined
来源
Genome Medicine | / 15卷
关键词
CRISPR; Cas9; Somatic multiplex-mutagenesis; Liver tumor; Intratumor genetic heterogeneity; eccDNA;
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