Small extrachromosomal circular DNA harboring targeted tumor suppressor gene mutations supports intratumor heterogeneity in mouse liver cancer induced by multiplexed CRISPR/Cas9

[1] Helleday T(2014)Mechanisms underlying mutational signatures in human cancers Nat Rev Genet 15 585-598

[2] Eshtad S(2017)Tumor evolution: linear, branching, neutral or punctuated? Biochim Biophys Acta Rev Cancer 1867 151-161

[3] Nik-Zainal S(2020)Intratumor heterogeneity: the Rosetta stone of therapy resistance Cancer Cell 37 471-484

[4] Davis A(2021)Cancer evolution: Darwin and beyond EMBO J 40 e108389-677

[5] Gao R(2013)Punctuated evolution of prostate cancer genomes Cell 153 666-41

[6] Navin N(2020)Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing Nat Genet 52 331-930

[7] Marusyk A(2017)Rebuilding chromosomes after catastrophe: emerging mechanisms of chromothripsis Trends Cell Biol 27 917-40

[8] Janiszewska M(2011)Massive genomic rearrangement acquired in a single catastrophic event during cancer development Cell 144 27-6505

[9] Polyak K(2011)Chromothripsis is a common mechanism driving genomic rearrangements in primary and metastatic colorectal cancer Genome Biol 12 R103-776

[10] Vendramin R(2015)Extremely high genetic diversity in a single tumor points to prevalence of non-Darwinian cell evolution Proc Natl Acad Sci U S A 112 E6496-593

[1] Helleday T(2014)Mechanisms underlying mutational signatures in human cancers Nat Rev Genet 15 585-598

[2] Eshtad S(2017)Tumor evolution: linear, branching, neutral or punctuated? Biochim Biophys Acta Rev Cancer 1867 151-161

[3] Nik-Zainal S(2020)Intratumor heterogeneity: the Rosetta stone of therapy resistance Cancer Cell 37 471-484

[4] Davis A(2021)Cancer evolution: Darwin and beyond EMBO J 40 e108389-677

[5] Gao R(2013)Punctuated evolution of prostate cancer genomes Cell 153 666-41

[6] Navin N(2020)Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing Nat Genet 52 331-930

[7] Marusyk A(2017)Rebuilding chromosomes after catastrophe: emerging mechanisms of chromothripsis Trends Cell Biol 27 917-40

[8] Janiszewska M(2011)Massive genomic rearrangement acquired in a single catastrophic event during cancer development Cell 144 27-6505

[9] Polyak K(2011)Chromothripsis is a common mechanism driving genomic rearrangements in primary and metastatic colorectal cancer Genome Biol 12 R103-776

[10] Vendramin R(2015)Extremely high genetic diversity in a single tumor points to prevalence of non-Darwinian cell evolution Proc Natl Acad Sci U S A 112 E6496-593