Synthesis and antiviral activity of fluorine-containing 4-arylaminoquinazolines

被引:0
作者
G. N. Lipunova
E. V. Nosova
A. A. Laeva
V. N. Charushin
机构
[1] Russian Academy of Sciences,I. Ya. Postovskii Institute of Organic Synthesis, Ural Branch
[2] B. N. Yeltsin Ural Federal University,undefined
来源
Pharmaceutical Chemistry Journal | 2012年 / 45卷
关键词
2-methylthio-4-phenylamino-6,7,8-trifluoro-3; -quinazolin-4-one; 6,7,8-trifluoro-2-ethylthioquinazolin-4-ones; synthesis; antiviral activity;
D O I
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学科分类号
摘要
2-Methylthio-4-phenylamino-6,7,8-trifluoro-3H-quinazolin-4-one was synthesized by means of intramolecular cyclizations of S-methyl-N-(tetrafluorobenzoyl)isothiourea followed by a reaction with POCl3 and nucleophilic substitution at the 4-position. The reactions of the synthesized compound with amines proceed, depending on their nature, via substitution of either the F(7) atom or the SMe fragment in the 2-position. The antiviral activity of the obtained 6,7,8-trifluoro-2-ethylthioquinazolin-4-ones was investigated using monkeypox virus, smallpox vaccine, and ectromelia virus. It is shown that fluorinated quinazoline derivatives have good prospects in the search for new active substances.
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页码:709 / 711
页数:2
相关论文
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Nosova EV(undefined)undefined undefined undefined undefined-undefined
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Lipunova GN(undefined)undefined undefined undefined undefined-undefined
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Laeva AA(undefined)undefined undefined undefined undefined-undefined