Searching for genetic determinants in the new millennium

被引：0
作者：
Neil J. Risch
机构：
[1] Stanford University School of Medicine,Department of Genetics
来源：
Nature | 2000年 / 405卷
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摘要：
Human genetics is now at a critical juncture. The molecular methods used successfully to identify the genes underlying rare mendelian syndromes are failing to find the numerous genes causing more common, familial, non-mendelian diseases. With the human genome sequence nearing completion, new opportunities are being presented for unravelling the complex genetic basis of non-mendelian disorders based on large-scale genome-wide studies. Considerable debate has arisen regarding the best approach to take. In this review I discuss these issues, together with suggestions for optimal post-genome strategies.
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页码：847 / 856
页数：9
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