Review on magnetic nanoparticle-mediated hyperthermia for cancer therapy

Biocompatible magnetic nanoparticle-mediated magnetic hyperthermia is an innovative, efficient, and safer thermo-therapeutic approach for cancer treatment. Structural and magnetic properties of magnetic nanoparticles as well as external magnetic field parameters are responsible for a controlled heating performance imperative for clinical success. This review covers topics from the nanophysics of magnetic nanoparticles through the basic concepts of magnetism to the different magnetic nanoparticles used for magnetic hyperthermia. Relevant properties beneficial for magnetic hyperthermia including size (nanosize regime of 10–100 nm), shape (anisotropic and isotropic), viscosity of the dispersive medium, and applied magnetic field parameters to optimize the heat dissipation via various mechanisms are also addressed. Primary aim of the present review is to provide an interdisciplinary knowledge platform for the basic understanding of nanomagnetism in order to advance further in the field of nanomedicine. This review pinpoints recent advancements in nanoparticle-tumor tissue interactions and their translation to clinical applications. The present review differs from other contemporary reviews by reporting the up-to-date developments in the nanotechnology aspects of magnetic hyperthermia and addressing the future perspectives.