Pan-cancer and multi-omics analyses revealed the diagnostic and prognostic value of BAZ2A in liver cancer

被引：0
作者：
Yan Liu
Junli Wang
Jimin Guo
Qianyi Zhang
Shuqing Wang
Fen Hu
Jinghua Wu
Yating Zhao
Jinghua Zhang
Yuan Yu
Yufeng Li
Xiaojun Zhang
机构：
[1] North China University of Science and Technology,College of Life Science
[2] Hebei Key Laboratory of Molecular Oncology,School of Public Health
[3] North China University of Science and Technology,Department of Clinical Laboratory
[4] Hospital of North China University of Science and Technology,Department of Breast Center
[5] North China University of Science and Technology Affiliated Tangshan Maternal and Child Health Hospital,The Cancer Institute
[6] North China University of Science and Technology Affiliated Hospital,Department of Oncology
[7] Tangshan People’s Hospital,undefined
[8] People’s Hospital of Zunhua,undefined
来源：
Scientific Reports | / 14卷
关键词：
BAZ2A; Enrichment analysis; Pan-cancer; Prognosis; LIHC;
D O I：
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学科分类号：
摘要：
BAZ2A, an epigenetic regulatory factor that affects ribosomal RNA transcription, has been shown to be highly expressed in several cancers and promotes tumor cell migration. This study explored the expression and mechanism of BAZ2A in tumorigenesis at the pan-cancer level. The Cancer Genome Atlas, Gene Expression Omnibus databases and TIMER2.0, cBioPortal and other tools were used to analyze the level of expression of BAZ2A in various tumor tissues and to examine the relationship between BAZ2A and survival, prognosis, mutation and immune invasion. In vitro experiments were performed to assess the function of BAZ2A in cancer cells. Using combined transcriptome and proteome analysis, we examined the possible mechanism of BAZ2A in tumors. BAZ2A exhibited high expression levels in multiple tumor tissues and displayed a significant association with cancer patient prognosis. The main type of BAZ2A genetic variation in cancer is gene mutation. Downregulation of BAZ2A inhibited proliferation, migration, and invasion and promoted apoptosis in LM6 liver cancer cell. The mechanism of BAZ2A in cancer development may involve lipid metabolism. These results help expand our understanding of BAZ2A in tumorigenesis and development and suggest BAZ2A may serve as a prognostic and diagnostic factor in several cancers.
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  • [1] Bray F(2018)Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries CA Cancer J. Clin. 68 394-424
  • [2] Sung H(2021)Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries CA Cancer J. Clin. 71 209-249
  • [3] Siegel RL(2019)Cancer statistics, 2019 CA Cancer J. Clin. 69 7-34
  • [4] Miller KD(2021)TC2N: A novel vital oncogene or tumor suppressor gene in cancers Front. Immunol. 12 1434-1443
  • [5] Jemal A(2022)Identification of a BAZ2A-bromodomain hit compound by fragment growing ACS Med. Chem. Lett. 13 1503-1518
  • [6] Li H(2019)GSK2801, a BAZ2/BRD9 bromodomain inhibitor, synergizes with BET inhibitors to induce apoptosis in triple-negative breast cancer Mol. Cancer Res. 17 5208-5220
  • [7] Dalle VA(2015)A novel RNA binding surface of the TAM domain of TIP5/BAZ2A mediates epigenetic regulation of rRNA genes Nucleic Acids Res. 43 80-92
  • [8] Bevill SM(2015)Molecular basis of histone tail recognition by human TIP5 PHD finger and bromodomain of the chromatin remodeling complex NoRC Structure 23 1633-1651
  • [9] Anosova I(2017)Structural basis of molecular recognition of helical histone H3 tail by PHD finger domains Biochem. J. 474 7645-7651
  • [10] Tallant C(2018)The transcription factor 7 like 2-binding protein TIP5 activates beta-catenin/transcription factor signaling in hepatocellular carcinoma Mol. Med. Rep. 17 22-30
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