Metastatic malignant phyllodes tumor of the breast: An aggressive disease—Analysis of 7 cases

被引：19

作者：

Ramakant P. ^{[1
]}

Selvamani ^{[2
]}

Therese M.M. ^{[3
]}

Paul M.J. ^{[1
]}

机构：

[1] Endocrine and Breast Surgery Department, Christian Medical College, Vellore, 632004, Tamil Nadu

[2] Radiation Oncology Department, Christian Medical College, Vellore

[3] Pathology Department, Christian Medical College, Vellore

来源：

Indian Journal of Surgical Oncology | 2015年 / 6卷 / 4期

关键词：

Distant metastases; Malignant phyllodes tumor of breast;

D O I：

10.1007/s13193-015-0397-9

中图分类号：

学科分类号：

摘要：

Malignant phyllodes tumor (PT) of the breast behaves aggressively and the presentation of distant metastases is varied, ranging from synchronous or short interval commonly to a decade rarely. To assess the clinical and temporal pattern of distant metastases in malignant PTs. A retrospective analysis of patients with Phyllodes tumor of the breast from January, 2001 to November, 2014. There were a total of 167 patients with PT; 49 (29 %) were malignant PT out of which 7 developed distant metastases. Detailed analysis of these 7 patients showed that mean age was 36.71 years (range 28-53 years). Three of the seven patients had additional local recurrences post lumpectomy. The procedure performed were wide local excision with muscle reconstruction (n= 1), lumpectomy (n=1) and mastectomy (n=5). The distant metastases were synchronous (n=2) and other 5 had metastases developing within 2 months to 13 years. The sites for distant metastases included lung, brain, adrenal, paraaortic nodes and bone. Six patients received palliative chemotherapy (CT) and 2 also had radiation therapy for brain metastasis. Only 1 patient is alive and receiving CT and all others succumbed to the disease. Patients with malignant PT of the breast with distant metastases behave aggressively and have a dismal outcome with rare exceptions. They need multimodality therapy and close follow up. Newer targeted therapies may have a role to improve the outcome. © Indian Association of Surgical Oncology 2015.

引用

页码：363 / 369

页数：6

共 18 条

[1]

Majeski J., Stroud J., Malignant phyllodes tumors of the breast: A study in clinical practice, Int Surg, 97, pp. 95-98, (2012)

[2]

Asoglu O., Karanlik H., Barbaros U., Yanar H., Kapran Y., Kecer M., Parlak M., Malignant phyllode tumor metastatic to the duodenum, World J Gastroenterol, 12, pp. 1649-1651, (2006)

[3]

Collin Y., Chagnon F., Mongeau C.J., Gonzalez-Amaya G.L., Sideris L., Adrenal metastasis of a phyllodes tumor of the breast: Case report and review of the literature, Int J Surg Case Rep, 4, pp. 687-689, (2013)

[4]

Serikawa M., Sasaki T., Kobayashi K., Itsuki H., Kamigaki M., Minami T., Et al., Malignant phyllodes tumor metastatic to the pancreas: A case report, Nihon Shokakibyo Gakkai Zasshi, 109, pp. 795-803, (2012)

[5]

Schechet S.A., Askenasy E.P., Dhamne S., Scott B.G., Anemia and jejuna intussusception: An unusual presentation for a metastatic phyllodes breast tumor, Int J Surg Case Rep, 3, pp. 62-64, (2012)

[6]

Garg N., Moorthy N., Agrawal S.K., Pandey S., Kumari N., Delayed cardiac metastasis from phyllodes breast tumor presenting as cardiogenic shock, Tex Heart Inst J, 38, pp. 441-444, (2011)

[7]

Kelly R.J., Barrett C., Swan N., McDermott R., Metastatic phyllodes tumor causing small-bowel obstruction, Clin Breast Cancer, 9, pp. 193-195, (2009)

[8]

Suarez Roa Mde L., Ruiz Godoy Rivera L.M., Vela Chavez T., Perez Sanchez M., Meneses Garcia A., Breast malignant phyllodes tumour metastasising to soft tissues of oral cavity, Clin Transl Oncol, 9, pp. 258-261, (2007)

[9]

Ramakant P., Chakravarthy S., Cherian J.A., Abraham D.T., Paul M.J., Challenges in management of phyllodes tumors of the breast: A retrospective analysis of 150 patients, Indian J Cancer, 50, pp. 345-348, (2013)

[10]

Sadatomo A., Hozumi Y., Shiozawa M., Hirashima Y., Koinuma K., Kurihara K., Spontaneous regression of pulmonary metastases from a malignant phyllodes tumor, Jpn J Clin Oncol, 41, pp. 915-917, (2011)

← 1 2 →