A numerical investigation was conducted into channel flows with a tandem of transverse vortex generators in the form of rectangular cylinders. The oscillatory behavior of the flow is studied. Data for heat transfer and flow losses are presented for 100≤Re≤400 and cylinder separation distances 1≤S/H≤4. The results are obtained by numerical solution of the full Navier-Stokes equations and the energy equation. Self-sustained flow oscillations are found for Re>100. Alternate and dynamic shedding of large vortex structures from the cylinders is observed by visualization of the numerically determined flow field. A heat transfer enhancement up to a factor 1.78 compared to plane channel flow is observed.