A Cost-Effectiveness Model Comparing Rivaroxaban and Dabigatran Etexilate with Enoxaparin Sodium as Thromboprophylaxis after Total Hip and Total Knee Replacement in the Irish Healthcare Setting

被引：0
|
作者：
Laura McCullagh
Lesley Tilson
Cathal Walsh
Michael Barry
机构：
[1] St James’s Hospital,National Centre for Pharmacoeconomics
[2] Trinity College Dublin,Department of Statistics
来源：
PharmacoEconomics | 2009年 / 27卷
关键词：
Deep Venous Thrombosis; Dabigatran; Rivaroxaban; Total Knee Replacement; Probabilistic Sensitivity Analysis;
D O I：
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学科分类号：
摘要：
Background: It has been estimated that major orthopaedic surgery has the highest risk of venous thromboembolism (deep vein thrombosis and pulmonary embolism) when compared with other surgery. Two new orally active anticoagulants have recently become licensed in Ireland for the primary prevention of venous thromboembolism in adult patients undergoing elective total hip replacement (THR) or total knee replacement (TKR). Rivaroxaban (Xarelto®) is a direct factor Xa inhibitor and dabigatran etexilate (Pradaxa®) is a prodrug of the active compound dabigatran, which inhibits thrombin.
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页码：829 / 846
页数：17
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