Effects of the Combined Treatment of Naloxone and Indomethacin on Catecholamines and Behavior After Intranigral Lipopolysaccharide Injection

被引：0
作者：
Vinchi Wang
Lie-Gan Chia
Dah-Ren Ni
Lee-Ju Cheng
Yuh-Pin Ho
Fu-Chou Cheng
Jau-Shyong Hong
机构：
[1] Cardinal Tien Hospital,Section of Neurology
[2] Taichung Veterans General Hospital,Department of Medical Research
[3] Fu-Jen Catholic University,School of Medicine
[4] Graduate Institute of Medical Sciences,Neuropharmacology Section Laboratory Pharmacology and Chemistry
[5] National Defense Medical Center,undefined
[6] NIEHS/NIH,undefined
[7] Research Triangle Park,undefined
来源：
Neurochemical Research | 2004年 / 29卷
关键词：
Naloxone; indomethacin; lipopolysaccharide; Parkinson's disease; catecholamines; behavior;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The present study examined effects of the combined administration of naloxone (NX) and indomethacin (IM) on nigrostriatal catecholamines and locomotor activity after intranigral lipopolysaccharide (LPS) injection in Sprague-Dawley rats. NX plus IM was given 3 days after LPS injection; it significantly (P < .05) reversed LPS inflammation on nigrostriatal dopamine (DA) and nigral serotonin (5-HT) and nigral homovanillic acid (HVA)/DA ratio and nigrostriatal 5-hydroxyindoleacetic acid (5-HIAA)/5-HT ratio. It also tended to ameliorate the locomotor hyperactivity. However, NX plus IM given 30 min before LPS could not satisfactorily protect against LPS's damage both biochemically and behaviorally. These results reveal that NX plus IM may protect against LPS on DA, 5-HT, and motor function after LPS injection but not before. Thus it suggests that the combined treatment of NX and IM gives a potent therapy, but not prevention, of LPS-induced inflammation and also protect nigrostriatal dopaminergic and serotoninergic systems against LPS in rats.
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页码：341 / 346
页数：5
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  • [1] Adolfsson R.(1979)Post-mortem distribution of dopamine and homovanillic acid in human brain, variations related to age, and a review of the literature J. Neural. Transm. 45 81-105
  • [2] Gottfries C. G.(1989)Aging and neurotoxins as causative factors in idiopathic PD: A critical analysis of the neurochemical evidence Prog. Neurol. Psychopharmacol. Biol. Psychiatry 13 319-328
  • [3] Roos B. E.(1988)Uneven pattern of dopamine loss in the striatum of patients with idiopathic Parkinson's disease: Pathophysiologic and clinical implications, New Engl J. Med. 318 876-880
  • [4] Winblad B. J.(1999)Etiology and pathogenesis of Parkinson's disease Annu. Rev. Neurosci. 22 123-144
  • [5] Hornykiewicz O.(1992)Differential effects of deprenyl and MPTP on catecholamines and activity in BALB/C mice Neuroreport 3 777-780
  • [6] Kish S. J.(1991)MPTP mechanism of neurotoxicity and their implications for Parkinson's disease Eur. J. Pharmacol. 208 273-286
  • [7] Shannak K.(1984)1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinsonism in the common marmoset Neurosci. Lett. 50 85-90
  • [8] Hornykiewicz O.(1995)Glia-dependent neurotoxicity and neuroprotection in mesencephalic culture Brain Res. 704 112-116
  • [9] Olanow C. W.(2000)Naloxone protects rat dopaminergic neurons against inflammatory damage through inhibition of microglia activation and superoxide generation J. Pharmcol. Exp. Ther. 293 607-617
  • [10] Tatton W. G.(1998)Lipopolysaccharide intranigral injection induces inflammatory reaction and damage in nigrostriatal dopaminergic system J. Neurochem. 70 1584-1592
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